Clinical Autonomic Research

, Volume 13, Issue 2, pp 96–98

Primary hyperhidrosis

Evidence for autosomal dominant inheritance
  • Horacio Kaufmann
  • Daniela Saadia
  • Charlene Polin
  • Stephen Hague
  • Amanda Singleton
  • Andrew Singleton
RESEARCH ARTICLE

DOI: 10.1007/s10286-003-0082-x

Cite this article as:
Kaufmann, H., Saadia, D., Polin, C. et al. Clin Auton Res (2003) 13: 96. doi:10.1007/s10286-003-0082-x

Abstract.

Primary hyperhidrosis is a neurogenic disorder of unknown cause characterized by excessive sweating in the palmar surface of the hands, armpits, groin and feet. In the course of a therapeutic trial for primary hyperhidrosis, 62 % of patients reported a positive family history. Examination of these pedigrees demonstrated a sibling recurrence risk of λs = 29–48 and an offspring recurrence risk of λo = 41–68 indicating that hyperhidrosis can be an inherited condition. The pattern of inheritance suggests an autosomal dominant mode of transmission with incomplete disease penetrance.

Key words: hyperhidrosisgeneticinheritanceautosomal dominant

Copyright information

© Steinkopff Verlag 2003

Authors and Affiliations

  • Horacio Kaufmann
    • 1
  • Daniela Saadia
    • 1
  • Charlene Polin
    • 2
  • Stephen Hague
    • 3
  • Amanda Singleton
    • 3
  • Andrew Singleton
    • 3
  1. 1.Dept. of Neurology, Mount Sinai School of Medicine, New York, USAUS
  2. 2.Dept. of Genetics, Mount Sinai School of Medicine, New York, USAUS
  3. 3.Laboratory of Neurogenetics, National Institute on Aging, National Institute of Health, Bethesda, USAUS
  4. 4.Mount Sinai School of Medicine, Box 1052, New York, NY 10029, USA. horacio.kaufmann@mssm.eduUS