Mycoscience

, Volume 53, Issue 1, pp 36–39

Gamma-aminobutyric acid (GABA) increases in vitro germ-tube formation and phospholipase B1 mRNA expression in Candidaalbicans

  • María Guadalupe Reyes-García
  • Francisca Hernández-Hernández
  • Fernando García-Tamayo
Short Communication

DOI: 10.1007/s10267-011-0130-7

Cite this article as:
Reyes-García, M.G., Hernández-Hernández, F. & García-Tamayo, F. Mycoscience (2012) 53: 36. doi:10.1007/s10267-011-0130-7

Abstract

Candida albicans is a commensal yeast in humans that disseminates in immunocompromised persons. Its spreading is modulated by melanin, hormones, or some neurotransmitters, among other factors. The neurotransmitter gamma-aminobutyric acid (GABA) is used by bacteria, plants, and fungi as a carbon and nitrogen source. In this article, the in vitro effect of different doses of GABA on germ-tube formation and expression of phospholipase B1 (PLB1) mRNA in two Candida albicans strains was investigated. Results demonstrated that GABA increases both germ-tube formation and PLB1 mRNA expression in the two Candida strains in a dose-dependent manner, which suggests that GABA promotes the growth of C. albicans.

Keywords

Germ tubes Neurotransmitter RT-PCR Virulence factors Yeasts 

Copyright information

© The Mycological Society of Japan and Springer 2011

Authors and Affiliations

  • María Guadalupe Reyes-García
    • 1
  • Francisca Hernández-Hernández
    • 2
  • Fernando García-Tamayo
    • 1
  1. 1.Laboratorio de Inmunobiología, Departamento de Biología. Facultad de QuímicaUniversidad Nacional Autónoma de MéxicoMexicoMexico
  2. 2.Laboratorio de Micología Médica Molecular, Departamento de Microbiología y Parasitología, Facultad de MedicinaUniversidad Nacional Autónoma de MéxicoMexicoMexico