Mycoscience

, Volume 51, Issue 2, pp 134–138

Effect of a hot water-soluble extraction from Grifola frondosa on the viability of a human monocyte cell line exposed to mitomycin C

  • Noriko Kodama
  • Shigeto Mizuno
  • Akihiro Asakawa
  • Akio Inui
  • Hiroaki Nanba
Short Communication

DOI: 10.1007/s10267-009-0016-0

Cite this article as:
Kodama, N., Mizuno, S., Asakawa, A. et al. Mycoscience (2010) 51: 134. doi:10.1007/s10267-009-0016-0
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Abstract

The effects of a hot water-soluble extract of Grifola frondosa on the viability of multiple immune cell lines were examined in vitro. The extract and the 1000-cut extract, a low molecular weight fraction, improved the viability of a human monocyte cell line, THP-1, treated by the anticancer drug mitomycin C. DNA microarray and immunoassay results revealed increases in interleukin (IL)-8 expression by THP-1 cells in response to the 1000-cut extract. These data suggest that the extract would enhance the immune system through induction of IL-8 production by human blood monocytes, which leads to activated neutrophils.

Keywords

Maitake mushroomIL-8ExtractViability

Copyright information

© The Mycological Society of Japan and Springer 2010

Authors and Affiliations

  • Noriko Kodama
    • 1
  • Shigeto Mizuno
    • 2
  • Akihiro Asakawa
    • 3
  • Akio Inui
    • 3
  • Hiroaki Nanba
    • 4
  1. 1.Department of Basic Educational Center for PharmacyKobe Pharmaceutical UniversityKobeJapan
  2. 2.Department of Medical PharmaceuticsKobe Pharmaceutical UniversityKobeJapan
  3. 3.Department of Behavioral MedicineKagoshima University Graduate School of Medical and Dental SciencesKagoshimaJapan
  4. 4.Kobe Pharmaceutical UniversityKobeJapan