Clinical and Experimental Medicine

, Volume 14, Issue 2, pp 133–140

A ticking clock links metabolic pathways and organ systems function in health and disease

  • Manlio Vinciguerra
  • Maria Florencia Tevy
  • Gianluigi Mazzoccoli
Review Article

DOI: 10.1007/s10238-013-0235-8

Cite this article as:
Vinciguerra, M., Tevy, M.F. & Mazzoccoli, G. Clin Exp Med (2014) 14: 133. doi:10.1007/s10238-013-0235-8

Abstract

Rhythmic variations with 24-h periodicity hallmark homeostatic regulation, metabolic processes and organ systems function, driven by a circadian timing system composed of central and peripheral oscillators. Recent reports suggest that disrupted circadian rhythmicity of physiology and behavior severely alters body homeostasis. Nuclear receptors and transcriptional regulators sense hormonal and metabolic cues and manage the rhythmic patterns of chromatin remodelling and gene expression, playing a key role in the cross talk between the circadian clock circuitry, the metabolic pathways and the organ systems. The alteration of this cross talk contributes to the pathophysiology of metabolic, degenerative, immune-related and neoplastic diseases.

Keywords

Circadian rhythm Clock gene Neuroendocrine-immune system Metabolism 

Copyright information

© Springer-Verlag Italia 2013

Authors and Affiliations

  • Manlio Vinciguerra
    • 1
  • Maria Florencia Tevy
    • 2
  • Gianluigi Mazzoccoli
    • 2
  1. 1.Division of Medicine, Institute of Liver and Digestive HealthUniversity College LondonLondonUK
  2. 2.Division of Internal Medicine and Chronobiology Unit, Department of Medical SciencesIRCCS Scientific Institute and Regional General Hospital “Casa Sollievo della Sofferenza,” Opera di Padre Pio da PietrelcinaSan Giovanni RotondoItaly

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