Clinical and Experimental Medicine

, Volume 11, Issue 1, pp 33–42

Hepcidin expression in anemia of chronic disease and concomitant iron-deficiency anemia

  • Pan-pan Cheng
  • Xiao-yang Jiao
  • Xue-hua Wang
  • Jing-hua Lin
  • Ying-mu Cai
Original Article

DOI: 10.1007/s10238-010-0102-9

Cite this article as:
Cheng, P., Jiao, X., Wang, X. et al. Clin Exp Med (2011) 11: 33. doi:10.1007/s10238-010-0102-9

Abstract

Hepcidin is a key hormone governing mammalian iron homeostasis and may be directly or indirectly involved in the development of most iron deficiency/overload and inflammation-induced anemia. The objective of this study was to investigate the expression of hepcidin in anemia of chronic disease. To characterize serum hepcidin, iron and inflammatory indicators associated with anemia of chronic disease (ACD), we studied ACD, ACD concomitant iron-deficiency anemia (ACD/IDA), pure IDA and acute inflammation (AcI) patients and analyzed the associations between hepcidin levels and inflammation parameters in various types of anemia. Serum hepcidin levels in patient groups were statistically different, from high to low: ACD, AcI > ACD/IDA > the control > IDA. Serum ferritin levels were significantly increased in ACD and AcI patients but were decreased significantly in ACD/IDA and IDA. Elevated serum EPO concentrations were found in ACD, ACD/IDA and IDA patients but not in AcI patients and the controls. A positive correlation between hepcidin and IL-6 levels only existed in ACD/IDA, AcI and the control groups. A positive correlation between hepcidin and ferritin was marked in the control group, while a negative correlation between hepcidin and ferritin was noted in IDA. The significant negative correlation between hepcidin expression and reticulocyte count was marked in both ACD/IDA and IDA groups. All of these data demonstrated that hepcidin might play role in pathogenesis of ACD, ACD/IDA and IDA, and it could be a potential marker for detection and differentiation of these anemias.

Keywords

Anemia of chronic disease Iron-deficiency anemia Hepcidin Erythropoietin IL-6 

Copyright information

© Springer-Verlag 2010

Authors and Affiliations

  • Pan-pan Cheng
    • 1
  • Xiao-yang Jiao
    • 1
  • Xue-hua Wang
    • 1
  • Jing-hua Lin
    • 1
  • Ying-mu Cai
    • 1
  1. 1.Department of Hemotology LaboratoryThe First Affiliated Hospital of Shantou University Medical CollegeShantou, GuangdongChina

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