Original Article

Clinical and Experimental Medicine

, Volume 10, Issue 2, pp 93-98

First online:

Intussusceptive microvascular growth in human glioma

  • Beatrice NicoAffiliated withDepartment of Human Anatomy and Histology, University of Bari Medical School
  • , Enrico CrivellatoAffiliated withDepartment of Medical and Morphological Research, Section of Anatomy, University of Udine Medical School
  • , Diego GuidolinAffiliated withDepartment of Human Anatomy and Physiology, Section of Anatomy, University of Padua Medical School
  • , Tiziana AnneseAffiliated withDepartment of Human Anatomy and Histology, University of Bari Medical School
  • , Vito LongoAffiliated withDepartment of Internal Medicine and Clinical Oncology, University of Bari Medical School
  • , Nicoletta FinatoAffiliated withDepartment of Medical and Morphological Research, Section of Pathology, University of Udine Medical School
  • , Angelo VaccaAffiliated withDepartment of Internal Medicine and Clinical Oncology, University of Bari Medical School
  • , Domenico RibattiAffiliated withDepartment of Human Anatomy and Histology, University of Bari Medical School Email author 

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Abstract

Intussusceptive microvascular growth (IMG), which occurs by splitting of the existing vasculature by transluminal pillars or transendothelial bridges, has been demonstrated in several tumors such as colon and mammary carcinomas, melanoma and B-cell non-Hodgkin’s lymphomas. In this study, we have correlated in human glioma the extent of angiogenesis, evaluated as microvascular density, the immunoreactivity of tumor cells to vascular endothelial growth factor (VEGF), vessel diameter and IMG to the tumor stage. Results demonstrate for the first time a relationship in human glioma progression between angiogenesis, VEGF immunoreactivity of tumor cells, vessel diameter and the number of connections of intraluminal tissue folds with the opposite vascular wall, expression of IMG and suggest that IMG could be a mechanism of compensatory vascular growth occurring in human glioma. The advantages are that (1) blood vessels are generated more rapidly; (2) it is energetically and metabolically more economic; (3) the capillaries thereby formed are less leaky.

Keywords

Glioblastoma Intussusceptive microvascular growth Tumor growth Vascular endothelial growth factor