Clinical and Experimental Medicine

, Volume 9, Issue 2, pp 157–163

ICAM-1 (Lys469Glu) and PECAM-1 (Leu125Val) polymorphisms in diffuse astrocytomas

  • Regislaine Valéria Burim
  • Silvia Aparecida Teixeira
  • Benedicto Oscar Colli
  • Fernanda Maris Peria
  • Luis Fernando Tirapelli
  • Suely Kazue Nagahashi Marie
  • Suzana Maria Fleury Malheiros
  • Sueli Mieko Oba-Shinjo
  • Alberto Alain Gabbai
  • Paulo Andrade Lotufo
  • Carlos Gilberto Carlotti-Júnior
Original Article

DOI: 10.1007/s10238-009-0040-6

Cite this article as:
Burim, R.V., Teixeira, S.A., Colli, B.O. et al. Clin Exp Med (2009) 9: 157. doi:10.1007/s10238-009-0040-6

Abstract

Cell adhesion molecules such as intercellular adhesion molecule-1 (ICAM-1) and platelet-endothelial cell adhesion molecule-1 (PECAM-1) play an important role in glioma invasion and angiogenesis. The aim of this study was to investigate whether specific genetic polymorphisms of ICAM-1 and PECAM-1 could be associated with glioma development and progression. Single-nucleotide polymorphism in codon 469 of ICAM-1 and codon 125 of PECAM-1 were examined in 158 patients with astrocytomas and 162 controls using polymerase chain reaction and restriction enzyme analysis. The distribution of PECAM-1 polymorphic genotypes in astrocytomas did not show any significant difference. However, a specific ICAM-1 genotype (G/G, corresponding to Lys469Glu) exhibited higher frequency in grade II astrocytomas compared to controls, grade III, and grade IV astrocytomas; suggesting that this polymorphism could be involved in the development of grade II astrocytomas.

Keywords

AstrocytomaPolymorphismPECAM-1ICAM-1

Copyright information

© Springer-Verlag 2009

Authors and Affiliations

  • Regislaine Valéria Burim
    • 1
    • 2
  • Silvia Aparecida Teixeira
    • 1
  • Benedicto Oscar Colli
    • 1
  • Fernanda Maris Peria
    • 3
  • Luis Fernando Tirapelli
    • 1
  • Suely Kazue Nagahashi Marie
    • 4
  • Suzana Maria Fleury Malheiros
    • 5
  • Sueli Mieko Oba-Shinjo
    • 6
  • Alberto Alain Gabbai
    • 5
  • Paulo Andrade Lotufo
    • 7
  • Carlos Gilberto Carlotti-Júnior
    • 1
  1. 1.Department of Surgery and Anatomy, Faculty of Medicine of Ribeirão PretoUniversity of São Paulo (USP)Ribeirão PretoBrazil
  2. 2.Department of Clinical, Toxicological and Bromatological Analysis, School of Pharmaceutical Sciences of Ribeirão Preto, FCFRPUniversity of São PauloRibeirão PretoBrazil
  3. 3.Department of Internal Medicine, Faculty of Medicine of Ribeirão PretoUniversity of São Paulo (USP)Ribeirão PretoBrazil
  4. 4.Department of Neurology, Faculty of MedicineUniversity of São Paulo (USP)São PauloBrazil
  5. 5.Department of Neurology, Faculty of MedicineFederal University of São Paulo (UNIFESP)São PauloBrazil
  6. 6.Department of Internal Medicine, Faculty of MedicineUniversity of São Paulo (USP)São PauloBrazil
  7. 7.São Paulo University HospitalUniversity of São Paulo (USP)São PauloBrazil