Biomechanics and Modeling in Mechanobiology

, Volume 13, Issue 1, pp 153–166

Osteocyte-viability-based simulations of trabecular bone loss and recovery in disuse and reloading

  • Hong Wang
  • Baohua Ji
  • X. Sherry Liu
  • René F. M. van Oers
  • X. Edward Guo
  • Yonggang Huang
  • Keh-Chih Hwang
Original Paper

DOI: 10.1007/s10237-013-0492-1

Cite this article as:
Wang, H., Ji, B., Liu, X.S. et al. Biomech Model Mechanobiol (2014) 13: 153. doi:10.1007/s10237-013-0492-1

Abstract

Osteocyte apoptosis is known to trigger targeted bone resorption. In the present study, we developed an osteocyte-viability-based trabecular bone remodeling (OVBR) model. This novel remodeling model, combined with recent advanced simulation methods and analysis techniques, such as the element-by-element 3D finite element method and the ITS technique, was used to quantitatively study the dynamic evolution of bone mass and trabecular microstructure in response to various loading and unloading conditions. Different levels of unloading simulated the disuse condition of bed rest or microgravity in space. The amount of bone loss and microstructural deterioration correlated with the magnitude of unloading. The restoration of bone mass upon the reloading condition was achieved by thickening the remaining trabecular architecture, while the lost trabecular plates and rods could not be recovered by reloading. Compared to previous models, the predictions of bone resorption of the OVBR model are more consistent with physiological values reported from previous experiments. Whereas osteocytes suffer a lack of loading during disuse, they may suffer overloading during the reloading phase, which hampers recovery. The OVBR model is promising for quantitative studies of trabecular bone loss and microstructural deterioration of patients or astronauts during long-term bed rest or space flight and thereafter bone recovery.

Keywords

Osteocyte viability Bone remodeling Trabecular bone Disuse Microgravity environment Osteoporosis 

Supplementary material

10237_2013_492_MOESM1_ESM.doc (4.1 mb)
Supplementary material 1 (doc 4216 KB)

Copyright information

© Springer-Verlag Berlin Heidelberg 2013

Authors and Affiliations

  • Hong Wang
    • 1
  • Baohua Ji
    • 2
  • X. Sherry Liu
    • 3
    • 4
  • René F. M. van Oers
    • 5
  • X. Edward Guo
    • 3
  • Yonggang Huang
    • 6
  • Keh-Chih Hwang
    • 1
  1. 1.Department of Engineering Mechanics, School of AerospaceTsinghua UniversityBeijingChina
  2. 2.Biomechanics and Biomaterial Laboratory, Department of Applied MechanicsBeijing Institute of TechnologyBeijingChina
  3. 3.Bone Bioengineering Laboratory, Department of Biomedical EngineeringColumbia UniversityNew YorkUSA
  4. 4.McKay Orthopaedic Research Laboratory, Department of Orthopaedic SurgeryUniversity of PennsylvaniaPhiladelphiaUSA
  5. 5.Dental Materials Science, Oral Cell BiologyAcademic Centre for Dentistry Amsterdam (ACTA)AmsterdamThe Netherlands
  6. 6.Department of Civil and Environmental EngineeringNorthwestern UniversityEvanstonUSA