Biomechanics and Modeling in Mechanobiology

, Volume 11, Issue 8, pp 1187–1204

Biomechanics of early cardiac development

  • Sevan Goenezen
  • Monique Y. Rennie
  • Sandra Rugonyi
Original Paper

DOI: 10.1007/s10237-012-0414-7

Cite this article as:
Goenezen, S., Rennie, M.Y. & Rugonyi, S. Biomech Model Mechanobiol (2012) 11: 1187. doi:10.1007/s10237-012-0414-7

Abstract

Biomechanics affect early cardiac development, from looping to the development of chambers and valves. Hemodynamic forces are essential for proper cardiac development, and their disruption leads to congenital heart defects. A wealth of information already exists on early cardiac adaptations to hemodynamic loading, and new technologies, including high-resolution imaging modalities and computational modeling, are enabling a more thorough understanding of relationships between hemodynamics and cardiac development. Imaging and modeling approaches, used in combination with biological data on cell behavior and adaptation, are paving the road for new discoveries on links between biomechanics and biology and their effect on cardiac development and fetal programming.

Keywords

Early cardiac developmentCardiogenesisComputational modelingComputational biomechanicsValveless pumpingBlood flow modeling

Copyright information

© Springer-Verlag 2012

Authors and Affiliations

  • Sevan Goenezen
    • 1
  • Monique Y. Rennie
    • 2
  • Sandra Rugonyi
    • 1
  1. 1.Department of Biomedical EngineeringOregon Health & Science UniversityPortlandUSA
  2. 2.Heart Research CenterOregon Health & Science UniversityPortlandUSA