Biomechanics and Modeling in Mechanobiology

, Volume 6, Issue 3, pp 163–175

Stress-driven collagen fiber remodeling in arterial walls

  • I. Hariton
  • G. deBotton
  • T. C. Gasser
  • G. A. Holzapfel
Original Paper

DOI: 10.1007/s10237-006-0049-7

Cite this article as:
Hariton, I., deBotton, G., Gasser, T.C. et al. Biomech Model Mechanobiol (2007) 6: 163. doi:10.1007/s10237-006-0049-7

Abstract

A stress-driven model for the relation between the collagen morphology and the loading conditions in arterial walls is proposed. We assume that the two families of collagen fibers in arterial walls are aligned along preferred directions, located between the directions of the two maximal principal stresses. For the determination of these directions an iterative finite element based procedure is developed. As an example the remodeling of a section of a human common carotid artery is simulated. We find that the predicted fiber morphology correlates well with experimental observations. Interesting outcomes of the model including local shear minimization and the possibility of axial compressions due to high blood pressure are revealed and discussed.

Keywords

Arterial wall Collagen fibers Finite element method Mechanical stress Remodeling Soft biological tissue 

Copyright information

© Springer-Verlag 2006

Authors and Affiliations

  • I. Hariton
    • 1
  • G. deBotton
    • 1
  • T. C. Gasser
    • 2
  • G. A. Holzapfel
    • 2
    • 3
  1. 1.The Pearlstone Center for Aeronautical Studies, Department of Mechanical EngineeringBen-Gurion UniversityBeer-ShevaIsrael
  2. 2.School of Engineering Sciences, Royal Institute of TechnologyStockholmSweden
  3. 3.Computational BiomechanicsGraz University of TechnologyGrazAustria