The European Journal of Health Economics

, Volume 11, Issue 4, pp 427–434

Mapping the QLQ-C30 quality of life cancer questionnaire to EQ-5D patient preferences

Original Paper

DOI: 10.1007/s10198-010-0233-7

Cite this article as:
Crott, R. & Briggs, A. Eur J Health Econ (2010) 11: 427. doi:10.1007/s10198-010-0233-7

Abstract

Background

Although cancer-specific Health-Related Quality of Life (HRQOL) are commonly included in randomized clinical trials or other prospective non-randomized clinical studies, it is rare that preference-based instruments are used that allow the calculation of a utility weight suitable for estimating quality-adjusted life-years gained.

Objective

To develop a mapping algorithm to transform the EORTC QLQ-C30 questionnaire responses into EQ-5D derived utilities.

Study design

Retrospective data analysis of a multicentre, multicountry prospective clinical trial in breast cancer patients.

Methods

Regression analysis of individual pairs of EQ-5D and QLQ-C30 scores.

Results

A model that explained 80% of the variance was developed to estimate EQ-5D Utilities from QLQ-C30 scores at individual level. From this reliable group level means and deviations can be derived.

Conclusions

Mapping from QLQ-C30 scores to EQ-5D-derived utilities when only QLQ-C30 data are available has been shown to be possible with good accuracy. Validation of the proposed algorithm in other external clinical datasets should be encouraged.

Keywords

CancerQLQ-C30EQ-5DPreferencesQuality of lifeMapping

JEL Classification

I19

Copyright information

© Springer-Verlag 2010

Authors and Affiliations

  1. 1.Academic Hospital St LucCatholic University of LouvainBrusselsBelgium
  2. 2.Section of Public Health and Health, Division of Community Based Sciences, Faculty of MedicineUniversity of GlasgowGlasgowUK