The European Journal of Health Economics

, Volume 11, Issue 1, pp 15–25

Cost-effectiveness of immunosuppressive regimens in renal transplant recipients in Germany: a model approach

  • Jan Steffen Jürgensen
  • Wolfgang Arns
  • Bastian Haß
Original Paper

DOI: 10.1007/s10198-009-0148-3

Cite this article as:
Jürgensen, J.S., Arns, W. & Haß, B. Eur J Health Econ (2010) 11: 15. doi:10.1007/s10198-009-0148-3

Abstract

Background

The choice of immunosuppression regimen is of paramount importance for outcomes and cost of renal transplantation. We compared the cost-effectiveness of triple immunosuppressive regimens in Germany.

Methods

A strong micro-simulation model was built comparing regimens based on cyclosporine, everolimus, sirolimus, and tacrolimus. Mean cost per patient, incremental cost per life year gained, and incremental cost per additional year with functioning graft were assessed from the perspective of the German statutory health insurance (SHI) after 2 and 10 years.

Results

Over the 2-year period, the model predicted mean total costs per patient of 26,732, 29,352, 33,415, and 49,978 € for sirolimus, cyclosporine, everolimus, and tacrolimus, respectively. Focusing on the cost per life year gained, the sirolimus-based regimen compared favorably with those based on everolimus and tacrolimus. The incremental cost-effectiveness ratio (ICER) of cyclosporine versus sirolimus is 524,000 € per life year gained. Regarding the cost per year with functioning graft gained, sirolimus dominated cyclosporine and everolimus, while the ICER for tacrolimus compared to sirolimus amounts to 1,788,154 €. Over the 10-year time frame, mean total costs per patient were 100,758, 108,300, 120,316, and 183,802 € for sirolimus, cyclosporine, everolimus, and tacrolimus, respectively. With regard to life years gained, sirolimus dominated both cyclosporine and everolimus. The ICER of tacrolimus versus sirolimus was 1,766,894 €. Considering the years with functioning graft gained, sirolimus dominated cyclosporine and everolimus, while the ICER for tacrolimus compared to sirolimus amounted to 1,339,419 €.

Conclusions

Over both the 2-year and the 10-year time horizon, sirolimus-based immunosuppression represents a cost-effective option in renal transplantation in Germany.

Keywords

Cost-effectivenessMarkov modelImmunosuppressionSirolimusRenal transplant

JEL Classification

D8H51I19

Copyright information

© Springer-Verlag 2009

Authors and Affiliations

  • Jan Steffen Jürgensen
    • 1
  • Wolfgang Arns
    • 2
  • Bastian Haß
    • 3
  1. 1.Department of Nephrology and Medical Intensive CareCharité-Universitaetsmedizin BerlinBerlinGermany
  2. 2.Kliniken der Stadt Köln GmbHCologneGermany
  3. 3.Health Economics and Outcomes ResearchIMS HEALTH GmbH & Co. OHGNurembergGermany