Brief Report

The Journal of Headache and Pain

, Volume 11, Issue 2, pp 167-169

Open Access This content is freely available online to anyone, anywhere at any time.

Angiotensin II receptor antagonists against migraine in pregnancy: fatal outcome

  • Kirsti HaalandAffiliated withDepartment of Pediatrics, Oslo University Hospital, Ullevål Email author 


A pregnant young woman with a severe migraine is prescribed candesartan, an angiotensin II type 1 receptor antagonist (AT II antagonists). This has a positive effect—except for severe maldevelopment of her fetus. There is an increase in the use of the fetotoxic drugs, AT II antagonists and angiotensin-converting enzyme inhibitors, as prophylactic treatment of migraines, in addition to their use as hypertensives.


Migraine Pregnancy Fetotoxic medication Angiotensin II receptor antagonist Angiotensin-converting enzyme inhibitor Hypertension