Original

The Journal of Headache and Pain

, Volume 10, Issue 2, pp 111-114

Open Access This content is freely available online to anyone, anywhere at any time.

Investigating the genetic role of aquaporin4 gene in migraine

  • Elisa RubinoAffiliated withNeurology II, Department of Neuroscience, University of Turin Email author 
  • , I. RaineroAffiliated withNeurology II, Department of Neuroscience, University of Turin
  • , G. VaulaAffiliated withNeurology II, Department of Neuroscience, University of Turin
  • , F. CrastoAffiliated withNeurology II, Department of Neuroscience, University of Turin
  • , E. GravanteAffiliated withNeurology II, Department of Neuroscience, University of Turin
  • , E. NegroAffiliated withNeurology II, Department of Neuroscience, University of Turin
  • , F. BregaAffiliated withNeurology II, Department of Neuroscience, University of Turin
  • , S. GalloneAffiliated withNeurology II, Department of Neuroscience, University of Turin
  • , L. PinessiAffiliated withNeurology II, Department of Neuroscience, University of Turin

Abstract

Aquaporin4 (AQP4) has an important role in water homeostasis of human brain and a dysfunction of AQP4 could induce pathological conditions in neuronal activity. The purpose of our work was to evaluate the association of polymorphisms in the AQP4 gene with the risk and the clinical features of migraine. A total of 293 migraineurs and 249 controls were involved in the study. They were genotyped for four single nucleotide polymorphisms (SNPs) of AQP4 gene. No significant difference in the distribution of AQP4 genotypic and allelic frequencies between cases and controls was found. In addition, haplotype analysis did not show any significant difference. Comparison of the clinical features of the disease according to different AQP4 genotypes showed no significant difference. Our data do not support the hypothesis that the AQP4 gene could represent a genetic susceptibility factor for migraine.

Keywords

Aquaporin4 Migraine without aura Migraine with aura Genetic association study