Brief Report

The Journal of Headache and Pain

, Volume 8, Issue 4, pp 245-247

Cluster headache attacks and multiple sclerosis

  • Salvatore GentileAffiliated withNeurology II — Headache Centre, Department of Neuroscience, University of Turin Email author 
  • , Margherita FerreroAffiliated withNeurology II — Headache Centre, Department of Neuroscience, University of Turin
  • , Giovanna VaulaAffiliated withNeurology II — Headache Centre, Department of Neuroscience, University of Turin
  • , Innocenzo RaineroAffiliated withNeurology II — Headache Centre, Department of Neuroscience, University of Turin
  • , Lorenzo PinessiAffiliated withNeurology II — Headache Centre, Department of Neuroscience, University of Turin

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Abstract

We report the case of a patient who developed typical cluster headache attacks and was diagnosed as having multiple sclerosis (MS) at the same time. The headache attacks resolved after i.v. treatment with methylprednisolone. MR imaging showed a pontine demyelinating lesion involving the trigeminal nerve root inlet area, on the same side as the pain. The association between cluster headache and MS has been rarely described before. This case suggests that in patients with cluster headache neuroimaging is often useful in order to exclude structural lesions.

Keywords

Cluster headache Multiple sclerosis Blink reflex Methylprednisolone