Invertebrate Neuroscience

, Volume 7, Issue 4, pp 209–217

Ion-channels on parasite muscle: pharmacology and physiology

Review

DOI: 10.1007/s10158-007-0059-x

Cite this article as:
Robertson, A.P. & Martin, R.J. Invert Neurosci (2007) 7: 209. doi:10.1007/s10158-007-0059-x

Abstract

Ion-channels are essential components of excitable cells. This fact has been exploited in the development of anthelmintic agents; the majority of which act on nematode ion channels. The purpose of this review is to describe the site of action of some frequently used anthelmintic compounds: nAChRs and levamisole/pyrantel; Glu-Cls and avermectins/mylbemycins; GABA receptors and piperazine. Also described is some of the physiological and pharmacological data on other nematode muscle ion-channels which may prove attractive targets for future anthelmintic development: Ca2+ activated Cl channels; peptide gated chloride Cl channels; Ca2+ channels and potassium channels. Emphasis is placed on the pharmacological and physiological data from parasite tissue. Information on the genes involved in ion-channel formation and modulation are reviewed in detail elsewhere in this issue.

Keywords

Anthelmintics nAChR Chloride channel Potassium channel Ca-channel Electrophysiology 

Copyright information

© Springer-Verlag 2007

Authors and Affiliations

  1. 1.Department of Biomedical SciencesIowa State UniversityAmesUSA

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