Invertebrate Neuroscience

, Volume 5, Issue 3, pp 119–133

Ion channels: molecular targets of neuroactive insecticides

Authors

  • Valérie Raymond-Delpech
    • MRC Functional Genetics Unit, Department of Human Anatomy and GeneticsUniversity of Oxford
    • Centre de Recherches sur la Cognition Animale, CNRS UMR 5169Université Paul Sabatier
  • Kazuhiko Matsuda
    • Department of Applied Biological Chemistry, School of AgricultureKinki University
  • Benedict M. Sattelle
    • MRC Functional Genetics Unit, Department of Human Anatomy and GeneticsUniversity of Oxford
  • James J. Rauh
    • Stine Haskell LaboratoryDupont Agricultural Products
    • MRC Functional Genetics Unit, Department of Human Anatomy and GeneticsUniversity of Oxford
Review

DOI: 10.1007/s10158-005-0004-9

Cite this article as:
Raymond-Delpech, V., Matsuda, K., Sattelle, B.M. et al. Invert Neurosci (2005) 5: 119. doi:10.1007/s10158-005-0004-9

Abstract

Many of the insecticides in current use act on molecular targets in the insect nervous system. Recently, our understanding of these targets has improved as a result of the complete sequencing of an insect genome, i.e., Drosophila melanogaster. Here we examine the recent work, drawing on genetics, genomics and physiology, which has provided evidence that specific receptors and ion channels are targeted by distinct chemical classes of insect control agents. The examples discussed include, sodium channels (pyrethroids, p,p′-dichlorodiphenyl-trichloroethane (DDT), dihydropyrazoles and oxadiazines); nicotinic acetylcholine receptors (cartap, spinosad, imidacloprid and related nitromethylenes/nitroguanidines); γ-aminobutyric acid (GABA) receptors (cyclodienes, γ-BHC and fipronil) and L-glutamate receptors (avermectins). Finally, we have examined the molecular basis of resistance to these molecules, which in some cases involves mutations in the molecular target, and we also consider the future impact of molecular genetic technologies in our understanding of the actions of neuroactive insecticides.

Keywords

Molecular targets of insecticidesSodium channelsIonotropic receptorsResistance genes

Copyright information

© Springer-Verlag 2005