Clinical and Experimental Nephrology

, Volume 16, Issue 3, pp 399–405

Relationship between serum cystatin C and serum adiponectin level in type 2 diabetic patients

  • Yoshiya Hosokawa
  • Yuya Yamada
  • Yoshinari Obata
  • Megu Yamaguchi Baden
  • Kenji Saisho
  • Arisa Ihara
  • Koji Yamamoto
  • Kiyonori Katsuragi
  • Yuji Matsuzawa
Original Article

DOI: 10.1007/s10157-011-0571-5

Cite this article as:
Hosokawa, Y., Yamada, Y., Obata, Y. et al. Clin Exp Nephrol (2012) 16: 399. doi:10.1007/s10157-011-0571-5

Abstract

Background

To investigate the relationship between serum levels of cystatin C and adiponectin in patients with type 2 diabetes.

Methods

We examined serum cystatin C and adiponectin levels in 234 patients with type 2 diabetes who visited our hospital.

Results

The serum level of cystatin C was positively correlated with age (P < 0.001), duration of diabetes (P = 0.013), serum creatinine (P < 0.001), uric acid (P < 0.001), and adiponectin (p = 0.001), while it was inversely correlated with estimated glomerular filtration rate (P < 0.001). Serum adiponectin was significantly higher in patients with high serum cystatin C levels than in those with normal cystatin C levels (8.3 ± 4.7 and 6.2 ± 3.2 μg/mL, respectively; P < 0.001). Adiponectin was also significantly higher in male patients with high cystatin C levels, but not in females. In multiple regression analysis, serum adiponectin was also independently and significantly correlated to age, diastolic blood pressure, high-density lipoprotein cholesterol, triglyceride and serum cystatin C.

Conclusions

Serum adiponectin level was correlated with serum cystatin C level on simple and multiple regression analyses in patients with type 2 diabetes. Although circulating adiponectin is increased in advanced kidney disease, it might be biologically inactive due to binding to cystatin C and thus not display an anti-arteriosclerotic effect.

Keywords

Cystatin C Adipocytokine Metabolic syndrome Diabetic nephropathy 

Copyright information

© Japanese Society of Nephrology 2011

Authors and Affiliations

  • Yoshiya Hosokawa
    • 1
  • Yuya Yamada
    • 1
  • Yoshinari Obata
    • 1
  • Megu Yamaguchi Baden
    • 1
  • Kenji Saisho
    • 1
  • Arisa Ihara
    • 1
  • Koji Yamamoto
    • 1
  • Kiyonori Katsuragi
    • 2
  • Yuji Matsuzawa
    • 1
  1. 1.Department of Endocrinology and MetabolismSumitomo HospitalOsakaJapan
  2. 2.Otsuka Pharmaceutical Co. LtdTokushimaJapan

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