Clinical and Experimental Nephrology

, Volume 16, Issue 1, pp 96–101

Clinical impact of albuminuria in diabetic nephropathy

  • Takashi Wada
  • Miho Shimizu
  • Tadashi Toyama
  • Akinori Hara
  • Shuichi Kaneko
  • Kengo Furuichi
Review Article

DOI: 10.1007/s10157-011-0508-z

Cite this article as:
Wada, T., Shimizu, M., Toyama, T. et al. Clin Exp Nephrol (2012) 16: 96. doi:10.1007/s10157-011-0508-z

Abstract

Patients suffering from diabetic nephropathy, resulting in end-stage renal failure, are increasing in number. The pathophysiology of diabetic nephropathy remains to be fully investigated. In the clinical setting, the presence of albuminuria/overt proteinuria and a low glomerular filtration rate may predict poor renal prognosis, but the prognosis of the normoalbuminuric renally insufficient diabetic patient remains controversial. In addition to the measurement of urinary albumin excretion, biomarker studies to detect diabetic nephropathy more specifically at the early stage have been performed worldwide. There is a growing body of evidence for remission and/or regression of diabetic nephropathy, which may be an indicator for cardiovascular and renal risk reduction. Deeper insights into the pathological characteristics as well as the clinical impact of albuminuria on renal and cardiovascular outcome are required.

Keywords

Diabetic nephropathyAlbuminuriaProteinuriaGlomerular filtration rateCardiovascular diseaseRenal outcome

Copyright information

© Japanese Society of Nephrology 2011

Authors and Affiliations

  • Takashi Wada
    • 1
  • Miho Shimizu
    • 2
  • Tadashi Toyama
    • 2
  • Akinori Hara
    • 2
  • Shuichi Kaneko
    • 3
  • Kengo Furuichi
    • 4
    • 5
  1. 1.Division of Nephrology, Department of Laboratory Medicine, Institute of Medical, Pharmaceutical and Health Sciences, Faculty of MedicineKanazawa UniversityKanazawaJapan
  2. 2.Division of Nephrology, Department of Disease Control and Homeostasis, Institute of Medical, Pharmaceutical and Health Sciences, Faculty of MedicineKanazawa UniversityKanazawaJapan
  3. 3.Department of Disease Control and Homeostasis, Institute of Medical, Pharmaceutical and Health Sciences, Faculty of MedicineKanazawa UniversityKanazawaJapan
  4. 4.Division of Blood purificationKanazawa University HospitalKanazawaJapan
  5. 5.Division of NephrologyKanazawa University HospitalKanazawaJapan