Renal preservation effect of ubiquinol, the reduced form of coenzyme Q10
Rent the article at a discountRent now
* Final gross prices may vary according to local VAT.Get Access
The aim of this study was to evaluate the renal preservation effect of ubiquinol, the reduced form of coenzyme Q10 (CoQ10).
Three-week-old heminephrectomized male Sprague–Dawley rats were divided into three groups (10 animals each): diet with normal (0.3%) salt, high (8%) salt, and high salt plus 600 mg/kg body weight/day of ubiquinol, for 4 weeks. Systolic blood pressure (SBP), urinary albumin (u-alb), superoxide anion generation (lucigenin chemiluminescence) and ubiquinol levels in renal tissues were examined.
Salt loading increased SBP (111.0 ± 3.6 vs. 169.4 ± 14.3 mmHg, p < 0.01) and u-alb (43.8 ± 28.0 vs. 2528.7 ± 1379.0 µg/day, p < 0.02). These changes were associated with stimulation of superoxide generation in the kidney (866.3 ± 102.8 vs. 2721.4 ± 973.3 RLU/g kidney, p < 0.01). However, ubiquinol decreased SBP (143.9 ± 29.0 mmHg, p < 0.05), u-alb (256.1 ± 122.1 µg/day, p < 0.02), and renal superoxide production (877.8 ± 195.6 RLU/g kidney, p < 0.01), associated with an increase in renal ubiquinol levels.
Ubiquinol, the reduced form of CoQ10, effectively ameliorates renal function, probably due to its antioxidant effect. Thus, ubiquinol may be a candidate for the treatment of patients with kidney disease.
- Lysaght, J (2002) Maintenance dialysis population dynamics: current trends and long-term implications. J Am Soc Nephrol 13: pp. S37-S40
- K/DOQI clinical practice guidelines for chronic kidney disease: evaluation, classification, and stratification. Am J Kidney Dis 39: pp. S1-S266
- Go, AS, Chertow, GM, Fan, D, McCulloch, CE, Hsu, CY (2004) Chronic kidney disease and the risks of death, cardiovascular events, and hospitalization. N Engl J Med 351: pp. 1296-1305 CrossRef
- Cachofeiro, V, Goicochea, M, Vinuesa, SG, Oubina, P, Lahera, V, Luno, J (2008) Oxidative stress and inflammation, a link between chronic kidney disease and cardiovascular disease. Kidney Int 74: pp. S4-S9 CrossRef
- Nagase, M, Yoshida, S, Shibata, S, Nagase, T, Gotoda, T, Ando, K (2006) Enhanced aldosterone signaling in the early nephropathy of rats with metabolic syndrome: possible contribution of fat-derived factors. J Am Soc Nephrol 17: pp. 3438-3446 CrossRef
- Liu, F, Wei, CC, Wu, SJ, Chenier, I, Zhang, SL, Filep, JG (2009) Apocynin attenuates tubular apoptosis and tubulointerstitial fibrosis in transgenic mice independent of hypertension. Kidney Int 75: pp. 156-166 CrossRef
- Manning, RD, Tian, N, Meng, S (2005) Oxidative stress and antioxidant treatment in hypertension and the associated renal damage. Am J Nephrol 25: pp. 311-317 CrossRef
- Hosoe, K, Kitano, M, Kishida, H, Kubo, H, Fujii, K, Kitahara, M (2007) Study on safety and bioavailability of ubiquinol (Kaneka QH) after single and 4-week multiple oral administration to healthy volunteers. Regul Toxicol Pharmacol 47: pp. 19-28 CrossRef
- Carlström, M, Sällström, J, Skøtt, O, Larsson, E, Persson, AE (2007) Uninephrectomy in young age or chronic salt loading causes salt-sensitive hypertension in adult rats. Hypertension 49: pp. 1342-1350 CrossRef
- Kitano, M, Watanabe, D, Oda, S, Kubo, H, Kishida, H, Fujii, K (2008) Subchronic oral toxicity of ubiquinol in rats and dogs. Int J Toxicol 27: pp. 189-215 CrossRef
- Matsui, H, Shimosawa, T, Uetake, Y, Wang, H, Ogura, S, Kaneko, T (2006) Protective effect of potassium against the hypertensive cardiac dysfunction: association with reactive oxygen species reduction. Hypertension 48: pp. 225-231 CrossRef
- Kishimoto, C, Tomioka, N, Nakayama, Y, Miyamoto, M (2003) Anti-oxidant effects of coenzyme Q10 on experimental viral myocarditis in mice. J Cardiovasc Pharmacol 42: pp. 588-592 CrossRef
- Bello, RI, Gómez-Díaz, C, Burón, MI, Alcaín, FJ, Navas, P, Villalba, JM (2005) Enhanced anti-oxidant protection of liver membranes in long-lived rats fed on a coenzyme Q10-supplemented diet. Exp Gerontol 40: pp. 694-706 CrossRef
- Mohr, D, Umeda, Y, Redgrave, TG, Stocker, R (1999) Antioxidant defenses in rat intestine and mesenteric lymph. Redox Rep 4: pp. 79-87 CrossRef
- Lim, SC, Tan, HH, Goh, SK, Subramanian, T, Sum, CF, Tan, IK (2006) Oxidative burden in prediabetic and diabetic individuals: evidence from plasma coenzyme Q10. Diabet Med 23: pp. 1344-1349 CrossRef
- Yamamoto, Y, Yamashita, S (1999) Plasma ubiquinone to ubiquinol ratio in patients with hepatitis, cirrhosis, and hepatoma, and in patients treated with percutaneous transluminal coronary reperfusion. Bio Factors 9: pp. 241-246
- Iwamoto, Y, Yamagami, T, Folkers, K, Blomqvist, CG (1974) Deficiency of coenzyme Q10 in hypertensive rats and reduction of deficiency by treatment with coenzyme Q10. Biochem Biophys Res Commun 58: pp. 743-748 CrossRef
- Mori, TA, Burke, V, Puddey, I, Irish, A, Cowpland, CA, Beilin, L (2009) The effects of [omega]3 fatty acids and coenzyme Q10 on blood pressure and heart rate in chronic kidney disease: a randomized controlled trial. J Hypertens 27: pp. 1863-1872 CrossRef
- Ho MJ, Bellusci A, Wright JM. Blood pressure lowering efficacy of coenzyme Q10 for primary hypertension. Cochrane Database Syst Rev. 2009;4:CD007435.
- Aberg, F, Appelkvist, EL, Dallner, G, Ernster, L (1992) Distribution and redox state of ubiquinones in rat and human tissues. Arch Biochem Biophys 295: pp. 230-234 CrossRef
- Kawarazaki H, Ando K, Nagae A, Fujita M, Matsui H, Fujita T. Mineralocorticoid receptor activation contributes to salt-induced hypertension and renal injury in prepubertal Dahl salt-sensitive rats. Nephrol Dial Transplant; 2010 (in press).
- Kido, M, Ando, K, Onozato, ML, Tojo, A, Yoshikawa, M, Ogita, T (2008) Protective effect of dietary potassium against the vascular injury in salt-sensitive hypertension. Hypertension 51: pp. 225-231 CrossRef
- Gregg, D, Rauscher, FM, Goldschmidt-Clermont, PJ (2003) Rac regulates cardiovascular superoxide through diverse molecular interactions: more than a binary GTP switch. Am J Physiol Cell Physiol 285: pp. C723-C734
- Vaziri, ND, Wang, XQ, Oveisi, F, Rad, B (2000) Induction of oxidative stress by glutathione depletion causes severe hypertension in normal rats. Hypertension 36: pp. 142-146
- Renal preservation effect of ubiquinol, the reduced form of coenzyme Q10
Clinical and Experimental Nephrology
Volume 15, Issue 1 , pp 30-33
- Cover Date
- Print ISSN
- Online ISSN
- Springer Japan
- Additional Links
- Oxidative stress
- Urinary albumin
- Chronic renal disease
- Industry Sectors
- Author Affiliations
- 1. Department of Urology, Graduate School of Medicine, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo, 113-8655, Japan
- 2. Department of Nephrology and Endocrinology, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan