Clinical and Experimental Nephrology

, Volume 14, Issue 6, pp 619–624

Successful treatment of lipoprotein glomerulopathy in a daughter and a mother using niceritrol

  • Hiroko Hamatani
  • Keiju Hiromura
  • Keiko Kobatake
  • Hiroaki Yoshida
  • Satsuki Kobayashi
  • Naohiro Yoneda
  • Ken Kayakabe
  • Takayuki Matsumoto
  • Takashi Kuroiwa
  • Kazue Ueki
  • Yoshihisa Nojima
Case Report

DOI: 10.1007/s10157-010-0333-9

Cite this article as:
Hamatani, H., Hiromura, K., Kobatake, K. et al. Clin Exp Nephrol (2010) 14: 619. doi:10.1007/s10157-010-0333-9

Abstract

We report two patients, a daughter and a mother, with lipoprotein glomerulopathy (LPG) who were successfully treated with niceritrol. Both patients carried a mutation in the apolipoprotein E (apoE) gene known as ApoE Tokyo/Maebashi. The daughter was found to have proteinuria at the age of 4 years. Four years later, she was diagnosed as having LPG based on a renal biopsy. She was treated with several medications including pravastatin, ethyl icosapentate, enalapril, warfarin and cyclophosphamide, all of which failed to reduce her proteinuria. At the age of 17 years, she exhibited an increase in proteinuria and a decline in renal function, despite ongoing treatment with pravastatin and enalapril. After switching from pravastatin to niceritrol, a marked reduction in the proteinuria and an improvement in renal function were observed. Her mother was found to have proteinuria at the age of 57 years and was diagnosed as having LPG based on a renal biopsy. She was also treated with niceritrol, resulting in an improvement in her proteinuria and renal function. These cases suggest that niceritrol might be a useful therapeutic option for LPG.

Keywords

Lipoprotein glomerulopathy Apolipoprotein E Niceritrol Proteinuria 

Copyright information

© Japanese Society of Nephrology 2010

Authors and Affiliations

  • Hiroko Hamatani
    • 1
  • Keiju Hiromura
    • 2
  • Keiko Kobatake
    • 1
  • Hiroaki Yoshida
    • 1
  • Satsuki Kobayashi
    • 1
  • Naohiro Yoneda
    • 2
  • Ken Kayakabe
    • 2
  • Takayuki Matsumoto
    • 2
  • Takashi Kuroiwa
    • 2
  • Kazue Ueki
    • 1
  • Yoshihisa Nojima
    • 2
  1. 1.Dialysis and Rheumatology CenterToho HospitalMidoriJapan
  2. 2.Department of Medicine and Clinical ScienceGunma University School of MedicineMaebashiJapan