, Volume 14, Issue 1, pp 100-101
Date: 06 Nov 2009

Accumulation of lanthanum carbonate in the digestive tracts

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Radio-opaque appearance of lanthanum carbonate

Lanthanum carbonate was made available in the United States in 2005, and in Japan in 2009. Lanthanum binds to phosphate ionically with low systemic absorption. Recent studies have demonstrated that ingested lanthanum carbonate can be detected on plain X-ray film [13]. We examined abdominal computed tomography (CT) scans to clarify its location more precisely in 9 HD patients (53 ± 2 [41–60] years old, male/female = 7/2) who had been taking it for 5–112 days. There were multiple calcium-like deposits throughout the digestive tracts of all of the patients (Fig. 1A). A case of 60-year-old women showed that a tablet that was swallowed without chewing was retained in the terminal ileum (Fig. 1B). Digested residues also accumulated into the colon diverticulum (Fig. 1C). It was recently demonstrated that the compound may cause or aggravate diverticular colitis, leading to increased serum concentrations of lanthanum [3]. Thus, lanthanum carbonate ...