Clinical and Experimental Nephrology

, Volume 10, Issue 1, pp 78–81

Bone marrow transplant nephropathy successfully treated with angiotensin-converting enzyme inhibitor

  • Shizunori Ichida
  • Keiko Okada
  • Michie Itoh
  • Rieko Okada
  • Noritoshi Katoh
  • Masanobu Kasai
  • Yukio Yuzawa
CASE REPORT

DOI: 10.1007/s10157-005-0394-3

Cite this article as:
Ichida, S., Okada, K., Itoh, M. et al. Clin Exp Nephrol (2006) 10: 78. doi:10.1007/s10157-005-0394-3

Abstract

We report a patient who developed chronic renal failure 11 months after an allogeneic hematopoietic stem-cell transplantation (HSCT) for Ph1+ acute lymphocytic leukemia. Renal biopsy showed typical pathological findings compatible with a bone marrow transplant nephropathy (BMT nephropathy). The general course of BMT nephropathy is slowly progressive, eventually reaching endstage renal failure. Intervention therapy with an angiotensin-converting enzyme inhibitor (ACE-I), temocapril, was started for this patient, based on several experimental reports showing the protective effects of ACE-Is on BMT nephropathy. After the induction of ACE-I in this patient, the rate of regression of renal function was significantly reduced and his serum creatinine was maintained at almost the same level for 18 months. Although the course of observation in this patient was short, we clearly showed the effects of an ACE-I on preventing BMT nephropathy from progressing to endstage renal failure in a human rather than in an experimental model.

Key words

Angiotensin-converting enzyme inhibitor BMT nephropathy Chronic renal failure Hematopoietic stem-cell transplantation Radiation nephritis 

Copyright information

© Japanese Society of Nephrology 2006

Authors and Affiliations

  • Shizunori Ichida
    • 1
  • Keiko Okada
    • 1
  • Michie Itoh
    • 1
  • Rieko Okada
    • 1
  • Noritoshi Katoh
    • 1
  • Masanobu Kasai
    • 2
  • Yukio Yuzawa
    • 3
  1. 1.Division of NephrologyJapanese Red Cross Nagoya First HospitalNagoyaJapan
  2. 2.Division of HematologyJapanese Red Cross Nagoya First HospitalNagoyaJapan
  3. 3.Division of Clinical Immunology, Department of MedicineNagoya University Graduate School of MedicineNagoyaJapan

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