Clinical and Experimental Nephrology

, Volume 9, Issue 2, pp 132–137

Prevalence of human polyoma virus (BK virus and JC virus) infection in patients with chronic renal disease

  • Tetsuya Kaneko
  • Toshiki Moriyama
  • Yoshiharu Tsubakihara
  • Masaru Horio
  • Enyu Imai
ORIGINAL ARTICLE

DOI: 10.1007/s10157-005-0348-9

Cite this article as:
Kaneko, T., Moriyama, T., Tsubakihara, Y. et al. Clin Exp Nephrol (2005) 9: 132. doi:10.1007/s10157-005-0348-9

Abstract

Background

Polyoma virus infection in renal transplant patients is sometimes critical in graft survival. But, to date, polyoma virus infection or reactivation has not been checked before renal transplantation. The prevalence of polyoma viruses (BK virus and JC virus) was investigated in 45 patients with renal disease who were future candidates as renal graft recipients.

Methods

Because these viruses are excreted in urine, the urine of these 45 patients was analyzed by polymerase chain reaction (PCR). The urine of 37 age-matched normal subjects (control group) was also investigated.

Results

In the control group, 13.5% of the normal subjects were positive for BK virus and 24.3% were positive for JC virus. In the patients with renal disease, 33.3% were positive for BK virus and 33.3% were positive for JC virus; the prevalence of BK virus infection was significantly higher than that in the normal subjects. Patients with renal disease with corticosteroid therapy revealed an especially high prevalence of BK virus infection (55.6%), indicating the possibility of viral reactivation by corticosteroid therapy.

Conclusions

More attention should be paid to polyoma virus infection in candidates for renal transplantation with a previous therapeutic history of corticosteroid administration.

Key words

BK virus JC virus Renal transplantation PCR Corticosteroid 

Copyright information

© Japanese Society of Nephrology 2005

Authors and Affiliations

  • Tetsuya Kaneko
    • 1
  • Toshiki Moriyama
    • 2
  • Yoshiharu Tsubakihara
    • 1
  • Masaru Horio
    • 3
  • Enyu Imai
    • 3
  1. 1.Department of NephrologyOsaka Prefectural General HospitalOsakaJapan
  2. 2.Health Care CenterOsaka UniversityOsakaJapan
  3. 3.Department of Internal Medicine and Therapeutics (A8)Osaka University Graduate School of MedicineOsakaJapan

Personalised recommendations