Urinary electrolytes and hypertension in elderly Kazakhs
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Background. Deficiency of potassium (K) intake is associated with hypertension, and high dietary K intake may have a preventive effect. The prevalence of hypertension and incidence of stroke are higher in Kazakhs than in other ethnic groups in the People's Republic of China (PRC). The Barkol area in the Xinjiang region in PRC is an area with a high population of Kazakhs. We carried out a study in this region that involved blood pressure monitoring and the examination of serum and urinary electrolytes in the Kazakh and Han populations of the area.
Methods. Twenty-four-hour ambulatory blood pressure monitoring and urine collections were performed for each study subject. In each subject, urine was collected simultaneously for 24 h during the blood pressure monitoring. Serum and urinary electrolytes were measured.
Results. The prevalence of hypertension was higher in the Kazakh population than in the Han (men, 53%; women, 43% in the Kazakhs; men, 40%; women, 30% in the Han; P < 0.001). Urinary excretion of potassium was lower in Kazakhs than in Han (Kazakh, 18.9 ± 8.7 mmol/day; Han, 36.5 ± 11.3 mmol/day; P < 0.001). Urinary excretion of sodium was lower in Kazakhs than in Han (Kazakhs, 181.4 ± 77.6 mmol/day; Han, 194.1 ± 75.9 mmol/day; P < 0.001). Mean 24-h blood pressure was higher in Kazaks than in Han, and this value correlated positively with the urinary sodium/potassium ratio (r = 0.39; P < 0.001).
Conclusions. The prevalence of hypertension was higher in Kazakhs than in Han in the Barkol area in the Xinjiang region. Kazakhs had a low intake of potassium. The sodium/potassium ratio was higher in Kazakhs than in Han. A high Na/K ratio, together with low intake of potassium, may be a factor in Kazakh hypertension.
- Urinary electrolytes and hypertension in elderly Kazakhs
Clinical and Experimental Nephrology
Volume 5, Issue 4 , pp 217-221
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- A1. Department of Internal Medicine, The Nippon Dental University School of Dentistry at Tokyo, 2-3-16 Fujimi, Chiyoda-ku, Tokyo 102-8158, Japan Tel. +81-3-3261-5638; Fax +81-3-3261-3924 e-mail: firstname.lastname@example.org, JP
- A2. Second Department of Medicine, Nihon University, School of Medicine, Itabashi hospital, Tokyo, Japan, JP
- A3. Department of Clinical Laboratory, Itabashi Hospital, Nihon University, Tokyo, Japan, JP
- A4. Department of Internal Medicine, The First Affiliated Hospital, Xinjiang Medical University, Urumqi, China, CN