A randomized clinical trial to evaluate the preventive effect of cranberry juice (UR65) for patients with recurrent urinary tract infection
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We examined the rate of relapse, as a variable index, in patients with urinary tract infection (UTI) who suffered from multiple relapses when using cranberry juice (UR65). A randomized, placebo-controlled, double-blind study was conducted from October 2007 to September 2009 in Japan. The subjects were outpatients aged 20 to 79 years who were randomly divided into two groups. One group received cranberry juice (group A) and the other a placebo beverage (group P). To keep the conditions blind, the color and taste of the beverages were adjusted. The subjects drank 1 bottle (125 mL) of cranberry juice or the placebo beverage once daily, before going to sleep, for 24 weeks. The primary endpoint was relapse of UTI. In the group of females aged 50 years or more, there was a significant difference in the rate of relapse of UTI between groups A and P (log-rank test; p = 0.0425). In this subgroup analysis, relapse of UTI was observed in 16 of 55 (29.1 %) patients in group A and 31 of 63 (49.2 %) in group P. In this study, cranberry juice prevented the recurrence of UTI in a limited female population with 24-week intake of the beverage.
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- A randomized clinical trial to evaluate the preventive effect of cranberry juice (UR65) for patients with recurrent urinary tract infection
Journal of Infection and Chemotherapy
Volume 19, Issue 1 , pp 112-117
- Cover Date
- Print ISSN
- Online ISSN
- Springer Japan
- Additional Links
- Recurrent urinary tract infection
- Industry Sectors
- Author Affiliations
- 1. Department of Urology, Sapporo Medical University School of Medicine, S1, W16, Chuo-ku, Sapporo, 0608543, Japan
- 10. Japanese UTI Research Group, Kitakyushu, Japan
- 2. Department of Urology, University of Occupational and Environmental Health, Kitakyushu, Japan
- 3. Department of Urology, Graduate School of Medicine, Gifu University, Gifu, Japan
- 4. Division of Urology, Department of Surgery Related Faculty of Medicine, Kobe University Graduate School of Medicine, Kobe, Japan
- 5. Department of Urology, School of Medicine, Fujita Health University, Toyoake, Japan
- 6. Department of Urology, The Jikei University Katsushika Medical Center, Tokyo, Japan
- 7. Department of Urology, Graduate School of Medical and Dental Sciences, Kagoshima University, Kagoshima, Japan
- 8. Department of Urology, Hyogo College of Medicine, Nishinomiya, Japan
- 9. Department of Public Health, University of Occupational and Environmental Health, Kitakyushu, Japan