Prognostic impacts of postoperative complications in patients with intrahepatic cholangiocarcinoma after curative operations

  • Tatsunori Miyata
  • Yo-ichi Yamashita
  • Takanobu Yamao
  • Naoki Umezaki
  • Masayo Tsukamoto
  • Yuki Kitano
  • Kensuke Yamamura
  • Kota Arima
  • Takayoshi Kaida
  • Shigeki Nakagawa
  • Katsunori Imai
  • Daisuke Hashimoto
  • Akira Chikamoto
  • Takatoshi Ishiko
  • Hideo Baba
Original Article

DOI: 10.1007/s10147-017-1099-9

Cite this article as:
Miyata, T., Yamashita, Y., Yamao, T. et al. Int J Clin Oncol (2017). doi:10.1007/s10147-017-1099-9

Abstract

Background

The postoperative complication is one of an indicator of poor prognosis in patients with several gastroenterological cancers after curative operations. We, herein, examined prognostic impacts of postoperative complications in patients with intrahepatic cholangiocarcinoma after curative operations.

Methods

We retrospectively analyzed 60 patients with intrahepatic cholangiocarcinoma who underwent primary curative operations from June 2002 to February 2016. Prognostic impacts of postoperative complications were analyzed using log-rank test and Cox proportional hazard model.

Results

Postoperative complications (Clavien-Dindo classification grade 3 or more) occurred in 13 patients (21.7%). Overall survival of patients without postoperative complications was significantly better than that of patients with postoperative complications (p = 0.025). Postoperative complications are independent prognostic factor of overall survival (hazard ratio 3.02; p = 0.030). In addition, bile duct resection and reconstruction (Odds ratio 59.1; p = 0.002) and hepatitis C virus antibody positive (Odds ratio 7.14; p= 0.022), and lymph node dissection (Odds ratio 6.28; p = 0.040) were independent predictors of postoperative complications.

Conclusion

Postoperative complications may be an independent predictor of poorer survival in patients with intrahepatic cholangiocarcinoma after curative operations. Lymph node dissection and bile duct resection and reconstruction were risk factors for postoperative complications, therefore we should pay attentions to perform lymph node dissections, bile duct resection and reconstruction in patients with intrahepatic cholangiocarcinoma.

Keywords

ICC Postoperative complication Prognosis Lymph node dissection 

Copyright information

© Japan Society of Clinical Oncology 2017

Authors and Affiliations

  • Tatsunori Miyata
    • 1
  • Yo-ichi Yamashita
    • 1
  • Takanobu Yamao
    • 1
  • Naoki Umezaki
    • 1
  • Masayo Tsukamoto
    • 1
  • Yuki Kitano
    • 1
  • Kensuke Yamamura
    • 1
  • Kota Arima
    • 1
  • Takayoshi Kaida
    • 1
  • Shigeki Nakagawa
    • 1
  • Katsunori Imai
    • 1
  • Daisuke Hashimoto
    • 1
  • Akira Chikamoto
    • 1
  • Takatoshi Ishiko
    • 1
  • Hideo Baba
    • 1
  1. 1.Department of Gastroenterological Surgery, Graduate School of Life SciencesKumamoto UniversityKumamotoJapan