Current Status of Uterine Leiomyosarcoma in the Tohoku Region: Results of the Tohoku Translational Center Development Network Survey

  • Hideki Tokunaga
  • Fumiaki Takahashi
  • Hiroki Yamamoto
  • Tsuyoshi Honda
  • Takafumi Watanabe
  • Tadahiro Shoji
  • Toru Sugiyama
  • Hidekazu Yamada
  • Tomoe Tando
  • Kosuke Yoshinaga
  • Satoko Kagabu
  • Takeo Otsuki
  • Shogo Kin
  • Yoshihito Yokoyama
  • Satoshige Wagatsuma
  • Kazuyo Sato
  • Hirokazu Sato
  • Takashi Oishi
  • Yuji Yoshida
  • Tadashi Hayasaka
  • Toshihiko Matsui
  • Noriaki Imai
  • Hidekazu Nishigori
  • Hiroaki Shimokawa
  • Nobuo Yaegashi
  • Yoh Watanabe
Original Article

DOI: 10.1007/s10147-017-1097-y

Cite this article as:
Tokunaga, H., Takahashi, F., Yamamoto, H. et al. Int J Clin Oncol (2017). doi:10.1007/s10147-017-1097-y

Abstract

Background

To prepare for a future clinical trial for improving the long-term prognosis of patients with uterine leiomyosarcoma (ULMS), we conducted a multi-institutional survey in the Tohoku region of Japan.

Methods

We conducted a retrospective cohort study between 2011 and 2014 in member institutions of the Tohoku Translational Research Center Development Network.

Results

A total of 53 patients with ULMS were registered in 31 institutions for the present survey. The median patient age was 56 years, 67.9% of the patients were postmenopausal, 88.7% had a performance status of 0 or 1, and only 6 patients (11.3%) showed preoperative evidence of malignancy. Although retroperitoneal lymphadenectomy was performed in only 26.4% of patients, 64.2% patients were identified as having FIGO stage 1 disease; 73.6% were eligible to undergo complete surgery. Among 36 patients who were treated with postoperative chemotherapy, 28 (77.8%) received docetaxel and gemcitabine combination therapy. The most frequent recurrence site was the lungs, and the median progression-free survival of all enrolled patients was 11.7 months. However, the median progression-free survival and the median overall survival in patients with stages III and IV disease were 3.4 and 11.4 months, respectively.

Conclusion

Although ULMS was associated with a high rate of complete or optimal surgery, the long-term prognosis was poor. Effective postoperative therapy should be developed to improve the long-term prognosis of patients with ULMS.

Keywords

Uterine leiomyosarcoma Tohoku region Retrospective survey 

Copyright information

© Japan Society of Clinical Oncology 2017

Authors and Affiliations

  • Hideki Tokunaga
    • 1
  • Fumiaki Takahashi
    • 2
  • Hiroki Yamamoto
    • 3
  • Tsuyoshi Honda
    • 4
  • Takafumi Watanabe
    • 5
  • Tadahiro Shoji
    • 6
  • Toru Sugiyama
    • 6
  • Hidekazu Yamada
    • 7
  • Tomoe Tando
    • 8
  • Kosuke Yoshinaga
    • 9
  • Satoko Kagabu
    • 10
  • Takeo Otsuki
    • 11
  • Shogo Kin
    • 12
  • Yoshihito Yokoyama
    • 13
  • Satoshige Wagatsuma
    • 14
  • Kazuyo Sato
    • 15
  • Hirokazu Sato
    • 16
  • Takashi Oishi
    • 17
  • Yuji Yoshida
    • 18
  • Tadashi Hayasaka
    • 19
  • Toshihiko Matsui
    • 20
  • Noriaki Imai
    • 21
  • Hidekazu Nishigori
    • 1
  • Hiroaki Shimokawa
    • 2
    • 22
  • Nobuo Yaegashi
    • 1
  • Yoh Watanabe
    • 2
    • 23
  1. 1.Department of Obstetrics and GynecologyTohoku University Graduate School of MedicineSendaiJapan
  2. 2.Clinical Research, Innovation and Education CenterTohoku University HospitalSendaiJapan
  3. 3.Department of Obstetrics and GynecologyOmagari Kousei Medical CenterOmagariJapan
  4. 4.Department of Obstetrics and GynecologyIwaki Kyoritsu HospitalIwakiJapan
  5. 5.Department of Obstetrics and GynecologyFukushima Medical UniversityFukushimaJapan
  6. 6.Department of Obstetrics and GynecologyIwate Medical University School of MedicineMoriokaJapan
  7. 7.Department of GynecologyMiyagi Cancer CenterNatoriJapan
  8. 8.Department of Obstetrics and GynecologyHirosaki National HospitalHirosakiJapan
  9. 9.Department of Obstetrics and GynecologySendai Medical CenterSendaiJapan
  10. 10.Department of Obstetrics and GynecologyNakadori General HospitalAkitaJapan
  11. 11.Department of Obstetrics and GynecologySendai City HospitalSendaiJapan
  12. 12.Department of Obstetrics and GynecologyTakeda General HospitalAizuwakamatsuJapan
  13. 13.Department of Obstetrics and GynecologyHirosaki University Graduate School of MedicineHirosakiJapan
  14. 14.Department of Obstetrics and GynecologyOsaki Citizen HospitalOsakiJapan
  15. 15.Department of Obstetrics and GynecologyIwate Prefectural Chubu HospitalKitakamiJapan
  16. 16.Department of Obstetrics and GynecologyJapanese Red Cross Akita HospitalAkitaJapan
  17. 17.Department of Obstetrics and GynecologyAomori Kousei HospitalAomoriJapan
  18. 18.Department of Obstetrics and GynecologyJapanese Red Cross Ishinomaki HospitalIshinomakiJapan
  19. 19.Department of Obstetrics and GynecologyNihonkai General HospitalSakataJapan
  20. 20.Department of Obstetrics and GynecologyNoshiro Kousei Medical CenterAkitaJapan
  21. 21.Department of Obstetrics and GynecologyHachinohe City HospitalHachinohe, AomoriJapan
  22. 22.Department of Cardiovascular MedicineTohoku University Graduate School of MedicineSendaiJapan
  23. 23.Department of Obstetrics and GynecologyTohoku Medical and Pharmaceutical UniversitySendaiJapan