Prognostic relevance of KRAS and BRAF mutations in Japanese patients with colorectal cancer
Rent the article at a discountRent now
* Final gross prices may vary according to local VAT.Get Access
Mutations of the KRAS or BRAF genes are now recognized as prognostic markers for colorectal cancer (CRC). They are also important predictive markers for resistance to the monoclonal antibodies that target the epidermal growth factor receptor.
In this retrospective study, KRAS and BRAF mutations were analyzed using a direct sequence method in 254 Japanese CRC patients, and the associations between KRAS or BRAF mutations and clinicopathological characteristics or outcome were evaluated.
KRAS and BRAF mutations were detected in 33.5 and 6.7 % of all patients, respectively. Consistent with previous reports, BRAF mutations were significantly correlated with the anatomical site of the tumor (P < 0.001), tumor grade (P = 0.001) and high frequency of microsatellite instability (P < 0.001). BRAF mutations were correlated with poor overall survival in the full patient cohort (P = 0.009). KRAS mutations were significantly correlated with poor recurrence-free survival (P = 0.03), particularly in patients with stage II CRC (P = 0.007). Cox regression analysis showed that KRAS mutations were a negative predictor of recurrence-free survival in patients with stage II CRC.
KRAS mutation status could be a novel biomarker for predicting disease recurrence in Japanese patients with stage II CRC.
- Prognostic relevance of KRAS and BRAF mutations in Japanese patients with colorectal cancer
International Journal of Clinical Oncology
Volume 18, Issue 6 , pp 1042-1048
- Cover Date
- Print ISSN
- Online ISSN
- Springer Japan
- Additional Links
- KRAS and BRAF mutations
- Colorectal cancer
- Prognostic factor
- Industry Sectors
- Author Affiliations
- 1. Department of Surgery and Science, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan
- 2. Department of Molecular Oncology, Graduate School of Medical Sciences, Kyushu University, 3-1-1 Maidashi, Higashi-ku, Fukuoka, 812-8582, Japan