, Volume 18, Issue 3, pp 492-497
Date: 25 Apr 2012

The relationship between urinary bisphenol A levels and meningioma in Chinese adults

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Abstract

Background

Estrogen has been implicated as a risk factor for meningioma. Bisphenol A (BPA), a widely used synthetic xenoestrogen, has already been reported to be associated with several estrogen-sensitive tumors.

Method

An exploratory association study of 243 meningioma cases and 258 frequency-matched healthy controls was conducted, using subjects from a hospital-based study to demonstrate the association of urine BPA concentration and the risk of meningioma. The specimens and data of patients were collected at Union Hospital, Wuhan, China, from 2009 to 2010.

Results

A positive association between increasing levels of urinary BPA and meningioma was observed, independent of confounding factors such as gender, age, race, body mass index, HRT use, BMI, and family history of cancer. Compared to quartile 1 (referent), the multivariate-adjusted odds ratio of meningioma associated with quartile 4 was 1.45 (95 % CI, 1.02–1.98) (P trend = 0.03).

Conclusion

In this case–control study from China, a clear association between urinary BPA concentrations and diagnosis of meningioma was detected.

B. Duan and X. Hu contributed equally to this work.