International Journal of Clinical Oncology

, Volume 18, Issue 3, pp 492–497

The relationship between urinary bisphenol A levels and meningioma in Chinese adults

Authors

  • Bo Duan
    • Department of Neurosurgery, Union HospitalHuazhong University of Science and Technology
    • Department of Neurosurgery, Taihe HospitalHubei University of Medicine
  • Xuebin Hu
    • Department of Neurosurgery, Union HospitalHuazhong University of Science and Technology
    • Department of Neurosurgery, Union HospitalHuazhong University of Science and Technology
  • Jun Qin
    • Department of Neurosurgery, Taihe HospitalHubei University of Medicine
  • Jie Luo
    • Department of Neurosurgery, Taihe HospitalHubei University of Medicine
Original Article

DOI: 10.1007/s10147-012-0408-6

Cite this article as:
Duan, B., Hu, X., Zhao, H. et al. Int J Clin Oncol (2013) 18: 492. doi:10.1007/s10147-012-0408-6

Abstract

Background

Estrogen has been implicated as a risk factor for meningioma. Bisphenol A (BPA), a widely used synthetic xenoestrogen, has already been reported to be associated with several estrogen-sensitive tumors.

Method

An exploratory association study of 243 meningioma cases and 258 frequency-matched healthy controls was conducted, using subjects from a hospital-based study to demonstrate the association of urine BPA concentration and the risk of meningioma. The specimens and data of patients were collected at Union Hospital, Wuhan, China, from 2009 to 2010.

Results

A positive association between increasing levels of urinary BPA and meningioma was observed, independent of confounding factors such as gender, age, race, body mass index, HRT use, BMI, and family history of cancer. Compared to quartile 1 (referent), the multivariate-adjusted odds ratio of meningioma associated with quartile 4 was 1.45 (95 % CI, 1.02–1.98) (P trend = 0.03).

Conclusion

In this case–control study from China, a clear association between urinary BPA concentrations and diagnosis of meningioma was detected.

Keywords

Urinary bisphenol A Meningioma Neurosurgery

Copyright information

© Japan Society of Clinical Oncology 2012