International Journal of Clinical Oncology

, Volume 17, Issue 4, pp 385–389

Thinking twice before abandoning first-line chemotherapy in ovarian cancer: report of two cases and literature review. Passing from tri-weekly to weekly regimens

  • Claudia Marchetti
  • Filippo Bellati
  • Angela Musella
  • Chiara Napoletano
  • Giorgia Perniola
  • Violante Di Donato
  • Sandro Pignata
  • Marianna Nuti
  • Pierluigi Benedetti Panici
Case Report

DOI: 10.1007/s10147-011-0300-9

Cite this article as:
Marchetti, C., Bellati, F., Musella, A. et al. Int J Clin Oncol (2012) 17: 385. doi:10.1007/s10147-011-0300-9
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Abstract

We present two cases of advanced ovarian cancer treated with neoadjuvant chemotherapy with standard tri-weekly carboplatin and paclitaxel. Therapy was converted to weekly regimens because of disease progression, resulting in disease response. Weekly regimens could overcome drug resistance and this strategy should be attempted before abandoning first-line chemotherapy in favor of palliation.

Keywords

Weekly paclitaxelCarboplatinOvarian cancer

Copyright information

© Japan Society of Clinical Oncology 2011

Authors and Affiliations

  • Claudia Marchetti
    • 1
  • Filippo Bellati
    • 1
    • 2
  • Angela Musella
    • 1
  • Chiara Napoletano
    • 2
  • Giorgia Perniola
    • 1
  • Violante Di Donato
    • 1
  • Sandro Pignata
    • 3
  • Marianna Nuti
    • 2
  • Pierluigi Benedetti Panici
    • 1
  1. 1.Department of Gynecology and Obstetrics“Sapienza” University of RomeRomeItaly
  2. 2.Department of Experimental Medicine“Sapienza” University of RomeRomeItaly
  3. 3.Medical OncologyNational Cancer InstituteNaplesItaly