Review Article

International Journal of Clinical Oncology

, Volume 13, Issue 4, pp 287-297

First online:

Molecular pathogenesis of bladder cancer

  • Margaret A. KnowlesAffiliated withCancer Research UK Clinical Centre, Leeds Institute of Molecular Medicine, St James’s University Hospital Email author 

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Bladder tumors show widely differing histopathology and clinical behavior. This is reflected in the molecular genetic alterations they contain. Much information has accumulated on somatic genomic alterations in bladder tumors of all grades and stages and when this information is related to the common histopathological appearances, a model for the pathogenesis of two major groups of bladder tumors has emerged. This review summarizes the genetic alterations that have been reported in bladder cancer and relates these to the current two-pathway model for tumor development. The molecular pathogenesis of high-grade noninvasive papillary tumors and of T1 tumors is not yet clear and possibilities are discussed.

Key words

Bladder Molecular pathogenesis Genetics Pathways