International Journal of Clinical Oncology

, Volume 12, Issue 4, pp 245–249

Sentinel node biopsy versus elective lymph node dissection in patients with cutaneous melanoma in a Japanese population

  • Arata Tsutsumida
  • Hiroshi Furukawa
  • Yuhei Yamamoto
  • Katsumi Horiuchi
  • Tetsunori Yoshida
  • Hidehiko Minakawa
  • Satoru Fujii
  • Naoki Murao
  • Hiroaki Kuwahara
  • Toshiyuki Minamimoto
  • Hirotaka Fujioka
  • Taisuke Sakamoto
  • Toyohiro Honma
ORIGINAL ARTICLE

DOI: 10.1007/s10147-007-0667-9

Cite this article as:
Tsutsumida, A., Furukawa, H., Yamamoto, Y. et al. Int J Clin Oncol (2007) 12: 245. doi:10.1007/s10147-007-0667-9
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Abstract

Background

In Japan, elective lymph node dissection (ELND) has been the standard treatment for patients with possible nodal melanoma. Sentinel node biopsy (SNB) has now replaced ELND, not only in Japan but also worldwide. The objective of this study was to compare the interim outcomes of SNB and ELND.

Methods

A retrospective study was conducted among patients with clinically node-negative disease treated at our institute with either SNB (n = 30) or ELND (n = 72).

Results

The background was similar in the two groups. Nodal metastases were found in 40.0% of patients in the SNB group, but in only 26.4% in the ELND group (P = 0.173). The median follow-up was 31.5 months for the SNB group and 82 months for the ELND group. The incidence of locoregional recurrence and distant metastasis in the SNB group was 10.0% and 16.7%, respectively, and for the ELND group the incidence was 5.6% and 31.9%, respectively. The 3-year disease-free survival rate was similar in the two groups (P = 0.280), and the 3-year disease-free survival rates for node-positive patients were also similar in the two groups (P = 0.90), as were the 3-year disease-free survival rates for node-negative patients (P = 0.193).

Conclusion

This interim result in a Japanese melanoma population with clinically node-negative disease demonstrated that SNB identified more nodal micrometastases than ELND. This increase in accurate staging likely resulted from the reliable identification of the lymph node field by lymphoscintigraphy, as well as the more detailed pathologic examination of the nodes removed in SNB. It is quite reasonable to perform SNB instead of ELND in this population.

Key words

Melanoma Sentinel lymph node biopsy Elective lymph node dissection Japanese population 

Copyright information

© The Japan Society of Clinical Oncology 2007

Authors and Affiliations

  • Arata Tsutsumida
    • 1
  • Hiroshi Furukawa
    • 1
  • Yuhei Yamamoto
    • 1
  • Katsumi Horiuchi
    • 2
  • Tetsunori Yoshida
    • 2
  • Hidehiko Minakawa
    • 3
  • Satoru Fujii
    • 4
  • Naoki Murao
    • 5
  • Hiroaki Kuwahara
    • 6
  • Toshiyuki Minamimoto
    • 7
  • Hirotaka Fujioka
    • 8
  • Taisuke Sakamoto
    • 9
  • Toyohiro Honma
    • 10
  1. 1.Department of Plastic and Reconstructive SurgeryGraduate School of Medicine, Hokkaido UniversitySapporoJapan
  2. 2.Department of Plastic and Reconstructive SurgerySapporo City General HospitalSapporoJapan
  3. 3.Department of Plastic and Reconstructive SurgeryHokkaido Cancer CenterSapporoJapan
  4. 4.Department of Plastic and Reconstructive SurgeryHakodate Municipal HospitalHakodateJapan
  5. 5.Department of Plastic and Reconstructive SurgeryKushiro Rosai HospitalKushiroJapan
  6. 6.Division of Plastic SurgeryObihiro Kohsei General HospitalObihiroJapan
  7. 7.Department of Plastic and Reconstructive SurgeryTomakomai Nisshou HospitalTomakomaiJapan
  8. 8.Department of Plastic and Reconstructive SurgeryBibai Rosai HospitalBibaiJapan
  9. 9.Department of Plastic and Reconstructive SurgeryNikko Memorial HospitalMuroranJapan
  10. 10.Department of Plastic and Reconstructive SurgeryKitami Red Cross HospitalKitamiJapan

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