International Journal of Clinical Oncology

, Volume 12, Issue 2, pp 131–136

Lymphatic invasion is a prognostic factor for bladder cancer treated with radical cystectomy

  • Yohei Horikawa
  • Teruaki Kumazawa
  • Shintaro Narita
  • Takamitsu Inoue
  • Takeshi Yuasa
  • Shinobu Matsuura
  • Hiroshi Nanjo
  • Shigeru Satoh
  • Norihiko Tsuchiya
  • Tomonori Habuchi
ORIGINAL ARTICLE

DOI: 10.1007/s10147-006-0637-7

Cite this article as:
Horikawa, Y., Kumazawa, T., Narita, S. et al. Int J Clin Oncol (2007) 12: 131. doi:10.1007/s10147-006-0637-7

Abstract

Background

We aimed to elucidate the significance of pathological prognostic factors in patients with bladder cancer treated with radical cystectomy and pelvic lymphadenectomy focusing on the association between lymphatic invasion and disease recurrence.

Methods

Ninety-one patients with ladder cancer who had undergone radical cystectomy were examined retrospectively. Clinicopathological findings and clinical outcomes were analyzed. Patients who received palliative cystectomy or neoadjuvant chemotherapy and patients who did not receive lymphadenectomy owing to a poor general condition or far advanced local disease status were excluded.

Results

Lymphatic invasion and lymph node involvement were present in 45.1% and 23.1% of patients, respectively. Multivariate analyses, using the Cox proportional hazards model, indicated that lymphatic invasion (hazard ratio [HR], 5.30; P = 0.007) and lymph node involvement (HR = 3.05; P = 0.016) were independent prognostic factors for disease-specific survival. Of the 91 patients, 29 (31.9%) had recurrent disease during the follow-up period. The rate of recurrence in patients with lymphatic invasion and without lymph node involvement was 50% (11/22), which was not significantly different from that in patients with both lymphatic invasion and lymph node involvement (73.7%; 14/19; P = 0.121), indicating a high risk of disease recurrence in patients with bladder cancer with lymphatic invasion even in the absence of the lymph node involvement.

Conclusion

In patients with bladder cancer treated with radical cystectomy, lymphatic invasion is an independent prognostic factor for disease-specific and disease-free survival. Patients with lymphatic invasion have a high risk of disease recurrence after radical cystectomy even in the absence of lymph node involvement.

Key words

Bladder cancerRadical cystectomyLymphatic invasion

Copyright information

© The Japan Society of Clinical Oncology 2007

Authors and Affiliations

  • Yohei Horikawa
    • 1
  • Teruaki Kumazawa
    • 1
  • Shintaro Narita
    • 1
  • Takamitsu Inoue
    • 1
  • Takeshi Yuasa
    • 1
  • Shinobu Matsuura
    • 1
  • Hiroshi Nanjo
    • 2
  • Shigeru Satoh
    • 1
  • Norihiko Tsuchiya
    • 1
  • Tomonori Habuchi
    • 1
  1. 1.Department of UrologyAkita University School of MedicineAkitaJapan
  2. 2.Department of PathologyAkita University School of MedicineAkitaJapan