REVIEW ARTICLE

International Journal of Clinical Oncology

, Volume 11, Issue 5, pp 344-350

First online:

Function-preserving surgery for breast cancer

  • Hideo InajiAffiliated withDepartment of Breast Surgery, Osaka Medical Center for Cancer and Cardiovascular Diseases, Osaka Prefectural Hospital Organization Email author 
  • , Chiyomi EgawaAffiliated withDepartment of Breast Surgery, Osaka Medical Center for Cancer and Cardiovascular Diseases, Osaka Prefectural Hospital Organization
  • , Yoshifumi KomoikeAffiliated withDepartment of Breast Surgery, Osaka Medical Center for Cancer and Cardiovascular Diseases, Osaka Prefectural Hospital Organization
  • , Kazuyoshi MotomuraAffiliated withDepartment of Breast Surgery, Osaka Medical Center for Cancer and Cardiovascular Diseases, Osaka Prefectural Hospital Organization
  • , Kinji NishiyamaAffiliated withDepartment of Radiation Oncology, Osaka Medical Center for Cancer and Cardiovascular Diseases, Osaka Prefectural Hospital Organization
  • , Tatsuki R. KataokaAffiliated withDepartment of Pathology, Osaka Medical Center for Cancer and Cardiovascular Diseases, Osaka Prefectural Hospital Organization
  • , Hiroki KoyamaAffiliated withDepartment of Breast Surgery, Osaka Medical Center for Cancer and Cardiovascular Diseases, Osaka Prefectural Hospital Organization

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Abstract

Breast-conserving treatment is well established as a safe method of treatment for the majority of breast cancers. Issues to be addressed concerning breast-conserving treatment include the omission of radiation therapy in low-risk patients, optimal local and systemic treatment for ipsilateral breast tumor recurrence, classification of ipsilateral breast tumor recurrence into true recurrences and new primary cancers, and the selection of patients who are eligible for breast conservation after neoadjuvant chemotherapy. There is much evidence that sentinel node biopsy is an accurate method of screening for axillary nodal status in patients with early breast cancer. Clearly, the avoidance of axillary dissection improves quality of life. The feasibility, accuracy, and timing of sentinel node biopsy in patients undergoing neoadjuvant chemotherapy are not yet clear. Also, the clinical significance of micrometastasis should be evaluated to determine the optimal application of sentinel node biopsy. There is interest in replacing breast-conserving treatment by nonsurgical ablation, although additional findings are needed to show that this technique is a true advance in breast cancer treatment.

Key words

Breast cancer Breast-conserving treatment Ipsilateral breast tumor recurrence Sentinel node biopsy Nonsurgical ablation