Functional & Integrative Genomics

, Volume 2, Issue 4, pp 199–211

Yeast and drug discovery

  • Timothy R. Hughes
Review

DOI: 10.1007/s10142-002-0059-1

Cite this article as:
Hughes, T.R. Funct Integr Genomics (2002) 2: 199. doi:10.1007/s10142-002-0059-1

Abstract.

Advanced genetic techniques, along with the high degree of conservation of basic cellular processes, have made the yeast Saccharomyces cerevisiae a valuable system for identification of new drug targets, target-based and non-target-based drug screening, and detailed analysis of the cellular effects of drugs. Yeast also presents a convenient system for antifungal drug discovery because it is closely related to Candida albicans, a major human pathogen. Many yeast genes remain poorly characterized, and most of the sophisticated techniques in yeast have been in widespread use less than a decade – a period shorter than the typical cycle from target identification to marketing approval for a new drug. It is likely that most of the benefits of yeast in discovery and development of therapeutic compounds have yet to be realized.

Yeast Drug discovery Pharmaceutical industry High-throughput screening

Copyright information

© Springer-Verlag 2002

Authors and Affiliations

  • Timothy R. Hughes
    • 1
  1. 1.Banting and Best Department of Medical Research, University of Toronto, 112 College St., Toronto, ON M5G 1L6, CanadaCanada