Functional & Integrative Genomics

, Volume 2, Issue 3, pp 98–104

Quantitative trait loci (QTL) for lean body mass and body length in MRL/MPJ and SJL/J F2 mice

  • Godfred L. Masinde
  • Xinmin Li
  • Weikuan Gu
  • Heather Davidson
  • Melanie Hamilton-Ulland
  • Jon Wergedal
  • Subburaman Mohan
  • David Baylink
Original Paper

DOI: 10.1007/s10142-002-0053-7

Cite this article as:
Masinde, G.L., Li, X., Gu, W. et al. Funct Integr Genomics (2002) 2: 98. doi:10.1007/s10142-002-0053-7

Abstract.

Studies on the genetic mechanisms involved in the regulation of lean body mass (LBM) in mammals are minimal, although LBM is associated with a competent immune system and an overall good (healthy) body functional status. In this study, we performed a high-density genome-wide scan using 633 (MRL/MPJ × SJL/J) F2 intercross to identify the quantitative trait loci (QTL) involved in the regulation of LBM. We hypothesized that additional QTL can be identified using a different mouse cross (MRL/SJL cross). Ten QTL were identified for LBM on chromosomes (chrs) 2, 6, 7, 9,13 and 14. Of those ten, QTL on chrs 6, 7 and 14 were exclusive to LBM, while QTL on chrs 4 and 11 were exclusively body length. LBM QTL on chrs 2 and 9 overlap with those of size. Altogether, the ten LBM QTL explained 41.2% of phenotypic variance in F2 mice. Five significantly interacting loci that may be involved in the regulation of LBM were identified and accounted for 24.4% of phenotypic variance explained by the QTL. Five epistatic interactions, contributing 22.9% of phenotypic variance, were identified for body length. Interacting loci on chr 2 may influence LBM by regulating body length. Therefore, epistatic interactions as well as single QTL effects play an important role in the regulation of LBM.

Lean body mass Quantitative trait loci Epistatic interactions 

Copyright information

© Springer-Verlag 2002

Authors and Affiliations

  • Godfred L. Masinde
    • 1
  • Xinmin Li
    • 1
  • Weikuan Gu
    • 1
  • Heather Davidson
    • 1
  • Melanie Hamilton-Ulland
    • 1
  • Jon Wergedal
    • 1
  • Subburaman Mohan
    • 1
  • David Baylink
    • 1
  1. 1.Molecular Genetics Division, Musculoskeletal Disease Center, J.L. Pettis VA Medical Center and Loma Linda University, 11201 Benton Street (151), Loma Linda, CA 92357, USA

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