Chinese Journal of Polymer Science

, Volume 29, Issue 3, pp 274–287

What can we learn from virus in designing nonviral gene vectors

  • Chun-hong Xu
  • Mei-hua Sui
  • Jian-bin Tang
  • You-qing Shen (申有青)
Review

DOI: 10.1007/s10118-011-1047-5

Cite this article as:
Xu, C., Sui, M., Tang, J. et al. Chin J Polym Sci (2011) 29: 274. doi:10.1007/s10118-011-1047-5
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Abstract

Gene therapy has emerged as a potential new approach to treat genetic disorders by delivering therapeutic genes to target diseased tissues. However, its clinical use has been impeded by gene delivery systems. The viral vectors are very efficient in delivering and expressing their carried genes, but they have safety issues in clinical use. While nonviral vectors are much safer with very low risks after careful material design, but their gene transcription efficiency is too low to be clinically used. Thus, rational design of nonviral vectors mimicking the viral vectors would be a way to break this bottleneck. This review compares side-by-side how viral/nonviral gene vectors transcend these biological barriers in terms of blood circulation, cellular uptake, endosome escape, nucleus import and gene transcription.

Keywords

Gene therapy Gene delivery Virus Nonviral vectors Cationic polymers 

Copyright information

© Chinese Chemical Society, Institute of Chemistry, Chinese Academy of Sciences and Springer-Verlag Berlin Heidelberg 2011

Authors and Affiliations

  • Chun-hong Xu
    • 1
  • Mei-hua Sui
    • 1
  • Jian-bin Tang
    • 1
  • You-qing Shen (申有青)
    • 1
  1. 1.Center for Bionanoengineering and Department of Chemical and Biological EngineeringZhejiang UniversityHangzhouChina

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