, Volume 27, Issue 6, pp 1233-1240
Date: 17 May 2012

Effect of irradiation with red and infrared laser in the treatment of oral mucositis

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Introduction

Oral mucositis (OM) is considered the cause of high morbidity and one of the main side effects of chemotherapy for antineoplastic treatment. The impact of OM on the patient’s health ranges from worsening quality of life during chemotherapy through to increased treatment costs [1, 2]. OM refers to lesions of the oral mucosa that vary from erythematous to ulcerative, and may result in various degrees of signs and symptoms, such as burning and pain when swallowing and speaking. These symptoms predispose the patient to nutritional disturbances and ulcerations may increase the risk of opportunist infections [2].

The drug 5-fluorouracil (5-FU) is an antimetabolite that works on the S-phase of the cell cycle, promoting DNA damage. It is used as a chemotherapeutic agent in the therapy of control and remission of various solid tumors, such as those of the gastrointestinal tract, breast and cervix. Its adverse effects are conditioned to the form of administration and dose, and involve ...