Lasers in Medical Science

, Volume 28, Issue 2, pp 669–682

Photodynamic therapy in the treatment of chronic periodontitis: a systematic review and meta-analysis

  • Fabrizio Sgolastra
  • Ambra Petrucci
  • Roberto Gatto
  • Giuseppe Marzo
  • Annalisa Monaco
Review Article

DOI: 10.1007/s10103-011-1002-2

Cite this article as:
Sgolastra, F., Petrucci, A., Gatto, R. et al. Lasers Med Sci (2013) 28: 669. doi:10.1007/s10103-011-1002-2

Abstract

This meta-analysis was conducted to investigate the efficacy and safety of antimicrobial photodynamic therapy used alone or adjunctive to scaling root planing in patients with chronic periodontitis. The meta-analysis was conducted according to the QUOROM statement and recommendations of the Cochrane Collaboration. An extensive literature search was performed on seven databases, followed by a manual search. Weighted mean differences and 95% confidence intervals were calculated for clinical attachment level, probing depth and gingival recession. The I2 test was used for inter-study heterogeneity; visual asymmetry inspection of the funnel plot, Egger’s regression test and the trim-and-fill method were used to investigate publication bias. At 3 months, significant differences in clinical attachment level (p = 0.006) and probing depth reduction (p = 0.02) were observed for scaling root planing with antimicrobial photodynamic therapy, while no significant differences were retrieved for antimicrobial photodynamic therapy used alone; at 6 months no significant differences were observed for any investigated outcome. Neither heterogeneity nor publication bias was detected. The use of antimicrobial photodynamic therapy adjunctive to conventional treatment provides short-term benefits, but microbiological outcomes are contradictory. There is no evidence of effectiveness for the use of antimicrobial photodynamic therapy as alternative to scaling root planing. Long-term randomized controlled clinical trials reporting data on microbiological changes and costs are needed to support the long-term efficacy of adjunctive antimicrobial photodynamic therapy and the reliability of antimicrobial photodynamic therapy as alternative treatment to scaling root planing.

Keywords

Chronic periodontitis Photodynamic therapy Photochemotherapy Non-surgical periodontal treatment Meta-analysis 

Copyright information

© Springer-Verlag London Ltd 2011

Authors and Affiliations

  • Fabrizio Sgolastra
    • 1
  • Ambra Petrucci
    • 1
  • Roberto Gatto
    • 1
  • Giuseppe Marzo
    • 1
  • Annalisa Monaco
    • 1
  1. 1.Department of Health SciencesUniversity of L’AquilaL’AquilaItaly

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