Lasers in Medical Science

, Volume 27, Issue 2, pp 469–477

Regulation of the cardiovascular function by CO2 laser stimulation in anesthetized rats

  • Thomas Friedemann
  • Xueyong Shen
  • Jürgen Bereiter-Hahn
  • Wolfgang Schwarz
Original Article

DOI: 10.1007/s10103-011-0973-3

Cite this article as:
Friedemann, T., Shen, X., Bereiter-Hahn, J. et al. Lasers Med Sci (2012) 27: 469. doi:10.1007/s10103-011-0973-3


Physical stimulation of body surface points is known to affect various organ functions. In traditional Chinese medicine, so-called acupoints were defined. These points can be physically stimulated to effectively treat various diseases. Here we describe for the first time the effect of CO2 laser stimulation at the acupoints Neiguan (PC-6), Quchi (LI-11), Zusanli (ST-36), and Taichong (LR-3) on heart rate and mean arterial blood pressure in anesthetized rats. CO2 laser stimulation increased the skin surface temperature to 54°C. Our results revealed that the laser stimulation at the left or right PC-6 and LR-3 increased heart rate and mean arterial pressure. There was no response of heart rate and mean arterial pressure during and after stimulation of the left LI-11, but laser stimulation at the right LI-11 slightly increased heart rate and mean arterial pressure. On the other hand, laser stimulation at the left and right ST-36 decreased heart rate and mean arterial pressure. The effects on mean arterial pressure were more pronounced than those on heart rate. After full spinal cord transection, all heart-rate and mean-arterial-pressure responses were attenuated or completely abolished. These results suggest that CO2 laser stimulation at either the left or right PC-6, ST-36, and LR-3, as well as at the right LI-11 can modulate the cardiovascular functions in anesthetized rats, and its modulatory site might be supraspinal.


CO2 laserBlood pressureHeart rateSpinalizationRat



LU-5 (Lung 5)


PC-6 (Pericardium 6)


LI-11 (Large intestine 11)


ST-36 (Stomach 36)


LR-3 (Liver 3)


Blood pressure


Central nervous system


Cardiovascular disease




Heart rate


Infrared laser stimulation


Mean arterial blood pressure


Standard error of the mean

Copyright information

© Springer-Verlag London Ltd 2011

Authors and Affiliations

  • Thomas Friedemann
    • 1
    • 2
  • Xueyong Shen
    • 3
  • Jürgen Bereiter-Hahn
    • 2
  • Wolfgang Schwarz
    • 1
    • 4
  1. 1.Shanghai Research Center for Acupuncture and MeridiansShanghaiChina
  2. 2.Institute for Cell BiologyGoethe-UniversityFrankfurt am MainGermany
  3. 3.Shanghai University of Traditional Chinese MedicineShanghaiChina
  4. 4.Institute for BiophysicsGoethe-UniversityFrankfurt am MainGermany