Lasers in Medical Science

, Volume 20, Issue 1, pp 11–20

Effect of LLLT Ga–Al–As (685 nm) on LPS-induced inflammation of the airway and lung in the rat

  • F. Aimbire
  • R. Albertine
  • R. G. de. Magalhães
  • R. A. B. Lopes-Martins
  • H. C. Castro-Faria-Neto
  • R. A. Zângaro
  • M. C. Chavantes
  • M. T. T. Pacheco
Original Article

DOI: 10.1007/s10103-005-0339-9

Cite this article as:
Aimbire, F., Albertine, R., Magalhães, R.G.. et al. Lasers Med Sci (2005) 20: 11. doi:10.1007/s10103-005-0339-9

Abstract

The purpose of this study was to investigate the effect of low level laser therapy (LLLT) on male Wistar rat trachea hyperreactivity (RTHR), bronchoalveolar lavage (BAL) and lung neutrophils influx after Gram-negative bacterial lipopolyssacharide (LPS) intravenous injection. The RTHR, BAL and lung neutrophils influx were measured over different intervals of time (90 min, 6 h, 24 h and 48 h). The energy density (ED) that produced an anti-inflammatory effect was 2.5 J/cm2, reducing the maximal contractile response and the sensibility of trachea rings to methacholine after LPS. The same ED produced an anti-inflammatory effect on BAL and lung neutrophils influx. The Celecoxib COX-2 inhibitor reduced RTHR and the number of cells in BAL and lung neutrophils influx of rats treated with LPS. Celecoxib and LLLT reduced the PGE2 and TXA2 levels in the BAL of LPS-treated rats. Our results demonstrate that LLLT produced anti-inflammatory effects on RTHR, BAL and lung neutrophils influx in association with inhibition of COX-2-derived metabolites.

Keywords

Lung Hyperreactivity Low level laser therapy LPS Prostanoids 

Copyright information

© Springer-Verlag London Limited 2005

Authors and Affiliations

  • F. Aimbire
    • 1
  • R. Albertine
    • 1
  • R. G. de. Magalhães
    • 1
  • R. A. B. Lopes-Martins
    • 1
  • H. C. Castro-Faria-Neto
    • 2
  • R. A. Zângaro
    • 1
  • M. C. Chavantes
    • 3
  • M. T. T. Pacheco
    • 1
  1. 1.Laboratório de Farmacologia e LASER, Instituto de Pesquisa & DesenvolvimentoUniversidade do Vale do Paraíba Av: Shishima HifumiSão José dos CamposBrazil
  2. 2.Laboratório de Fisiologia e FarmacodinâmicaInstituto Oswaldo Cruz, FIOCRUZRio de JaneiroBrazil
  3. 3.Departamento de Laser em BiomedicinaInstituto do CoraçãoSão PauloBrazil