Lasers in Medical Science

, Volume 18, Issue 3, pp 171–176

Using the laser-induced fluorescence spectroscopy in the differentiation between normal and neoplastichuman breast tissue

  • R. Hage
  • P. R. Galhanone
  • R. A. Zângaro
  • K. C. Rodrigues
  • M. T. T. Pacheco
  • A. A. Martin
  • M. M. Netto
  • F. A. Soares
  • I. W. da Cunha
Article

DOI: 10.1007/s10103-003-0271-9

Cite this article as:
Hage, R., Galhanone, P., Zângaro, R. et al. Lasers Med Sci (2003) 18: 171. doi:10.1007/s10103-003-0271-9

Abstract

This article reports results of the in vitro study for potential evaluation of the laser-induced fluorescence spectroscopy in the differentiation between normal and neoplastic human breast tissue. A coumarine dye laser pumped by nitrogen laser generated an excitation light centered at 458 nm. In order to collect the fluorescence signal was used an optical fiber catheter coupled to a spectrometer and CCD detector. Fluorescence spectra were recorded from normal and neoplastic (benign and malignant) human breast tissue, adding up 94 different areas. The discrimination between normal and neoplasm groups reach a sensitivity and specificity of 100%.

Keywords

Breast cancerFluorescence spectroscopy

Copyright information

© Springer-Verlag London Limited 2003

Authors and Affiliations

  • R. Hage
    • 1
    • 3
  • P. R. Galhanone
    • 1
  • R. A. Zângaro
    • 1
  • K. C. Rodrigues
    • 1
  • M. T. T. Pacheco
    • 1
  • A. A. Martin
    • 1
  • M. M. Netto
    • 2
  • F. A. Soares
    • 2
  • I. W. da Cunha
    • 2
  1. 1.IP&DUniversidade do Vale do ParaíbaSPBrazil
  2. 2.Hospital do Câncer A.C. CamargoSPBrazil
  3. 3.IP&DUniversidade do Vale do ParaíbaUrbanovaBrazil