Disseminated Infection due to Nocardia transvalensis Coincident with Cryptococcus neoformans variety gattii Meningitis

  • J. R. Dyer
  • N. Ketheesan
  • R. E. Norton
  • C. I. J. Ashhurst-Smith
  • P. Keary
  • J. T. La Brooy
Note

DOI: 10.1007/s100960050352

Cite this article as:
Dyer, J., Ketheesan, N., Norton, R. et al. EJCMID (1999) 18: 587. doi:10.1007/s100960050352

Abstract

 A case of meningitis due to Cryptococcus neoformans var. gattii coincident with disseminated Nocardia transvalensis infection is reported. Nocardia infection initially progressed despite high-dose antimicrobial therapy. Although a specific immunologic defect could not be defined, in vitro lymphocyte proliferation in response to stimulation with the Nocardia isolate was reduced. It is proposed that coinfection with Cryptococcus neoformans may have contributed to the observed impairment of lymphocyte function, leading to disseminated Nocardia disease and a suboptimal treatment response.

Copyright information

© Springer-Verlag Berlin Heidelberg 1999

Authors and Affiliations

  • J. R. Dyer
    • 1
  • N. Ketheesan
    • 3
  • R. E. Norton
    • 2
  • C. I. J. Ashhurst-Smith
    • 4
  • P. Keary
    • 5
  • J. T. La Brooy
    • 2
  1. 1.Infectious Diseases Unit, St. Andrew's Hospital, PO Box 839, Ipswich 4305, Queensland, Australia e-mail: jdyer@medeserv.com.auAU
  2. 2.Infectious Diseases Unit, Townsville General Hospital, Townsville 4810, Queensland, AustraliaAU
  3. 3.Department of Medicine, North Queensland Clinical School, University of Queensland, PO Box 480, Townsville 4810, Queensland, AustraliaAU
  4. 4.Department of Microbiology, Townsville General Hospital, Townsville 4810, Queensland, AustraliaAU
  5. 5.Department of General Medicine, Townsville General Hospital, Townsville 4810, Queensland, AustraliaAU

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