European Journal of Clinical Microbiology and Infectious Diseases

, Volume 19, Issue 1, pp 53–56

Clinical Significance of Scedosporium apiospermum in Patients with Cystic Fibrosis

Authors

  • B. Cimon
    • Laboratoire de Parasitologie-Mycologie, Centre Hospitalier Universitaire, 4 rue Larrey, 49033 Angers Cedex 01, France e-mail: Becimon@chu-angers.fr
  • J. Carrère
    • Hôpital Renée Sabran, Giens, 83406 Hyères Cedex, France
  • J. F. Vinatier
    • Laboratoire de Parasitologie-Mycologie, Centre Hospitalier Universitaire, 4 rue Larrey, 49033 Angers Cedex 01, France e-mail: Becimon@chu-angers.fr
  • J. P. Chazalette
    • Hôpital Renée Sabran, Giens, 83406 Hyères Cedex, France
  • D. Chabasse
    • Laboratoire de Parasitologie-Mycologie, Centre Hospitalier Universitaire, 4 rue Larrey, 49033 Angers Cedex 01, France e-mail: Becimon@chu-angers.fr
  • J. P. Bouchara
    • Laboratoire de Parasitologie-Mycologie, Centre Hospitalier Universitaire, 4 rue Larrey, 49033 Angers Cedex 01, France e-mail: Becimon@chu-angers.fr
Note

DOI: 10.1007/s100960050011

Cite this article as:
Cimon, B., Carrère, J., Vinatier, J. et al. EJCMID (2000) 19: 53. doi:10.1007/s100960050011

Abstract

 The incidence of airway colonization by Scedosporium apiospermum and of related sensitization was investigated prospectively in 128 patients with cystic fibrosis over a 5-year period, and results were compared with clinical data. Scedosporium apiospermum, recovered from sputum samples in 11 of 128 (8.6%) patients, was the most frequent filamentous fungus after Aspergillus fumigatus. Counterimmunoelectrophoresis, used to detect scedosporiosis serologically, was positive in 27 of 128 (21.1%) patients. The discrepancy between the mycological and serological results may be related to immune cross-reactions between Scedosporium apiospermum and Aspergillus fumigatus. However, symptoms of allergic bronchopulmonary disease were observed in two patients chronically colonized by Scedosporium apiospermum. The results clearly demonstrate that the frequency of this fungus is largely underestimated and that it may trigger an inflammatory response, thus suggesting a pathogenic role in patients with cystic fibrosis.

Copyright information

© Springer-Verlag Berlin Heidelberg 2000