A large outbreak of Opisthorchis felineus in Italy suggests that opisthorchiasis develops as a febrile eosinophilic syndrome with cholestasis rather than a hepatitis-like syndrome

  • A. Traverso
  • E. Repetto
  • S. Magnani
  • T. Meloni
  • M. Natrella
  • P. Marchisio
  • C. Giacomazzi
  • P. Bernardi
  • S. Gatti
  • M. A. Gomez Morales
  • E. Pozio
Article

DOI: 10.1007/s10096-011-1411-y

Cite this article as:
Traverso, A., Repetto, E., Magnani, S. et al. Eur J Clin Microbiol Infect Dis (2012) 31: 1089. doi:10.1007/s10096-011-1411-y

Abstract

We describe the greatest Italian human acute opisthorchiasis outbreak acquired from eating raw tenches. Out of 52 people with suspected opisthorchiasis, 45 resulted in being infected. The most frequent symptoms and laboratory findings were fever, abdominal pain and eosinophilia. Seven tri-phasic computed tomography (CT) scans were done, showing multiple hypodense nodules with hyper-enhancement in the arterial phase. All patients took one day of praziquantel 25 mg/kg TID without failures. Reported symptoms suggested a febrile eosinophilic syndrome with cholestasis rather than a hepatitis-like syndrome. It seems common to find hepatic imaging alterations during acute opisthorchiasis: CT scan could be the most suitable imaging examination. Even if stool test remains the diagnostic gold standard, we found earlier positivity with the serum antibody test. Without previous freezing, the consumption of raw freshwater fish should be avoided.

Copyright information

© Springer-Verlag 2011

Authors and Affiliations

  • A. Traverso
    • 1
  • E. Repetto
    • 1
  • S. Magnani
    • 1
  • T. Meloni
    • 2
  • M. Natrella
    • 2
  • P. Marchisio
    • 2
  • C. Giacomazzi
    • 3
  • P. Bernardi
    • 4
  • S. Gatti
    • 5
  • M. A. Gomez Morales
    • 6
  • E. Pozio
    • 6
  1. 1.Infectious Diseases Unit“U. Parini” HospitalAostaItaly
  2. 2.Radiology Service“U. Parini” HospitalAostaItaly
  3. 3.Microbiology Service“U. Parini” HospitalAostaItaly
  4. 4.Anatomic Pathology Service“U. Parini” HospitalAostaItaly
  5. 5.Virology and Microbiology Unit“S. Matteo Hospital”PaviaItaly
  6. 6.Department of Infectious, Parasitic and Immunomediated DiseasesIstituto Superiore di SanitàRomeItaly

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