European Journal of Clinical Microbiology & Infectious Diseases

, Volume 31, Issue 1, pp 7-20

Coagulase-negative staphylococci: update on the molecular epidemiology and clinical presentation, with a focus on Staphylococcus epidermidis and Staphylococcus saprophyticus

  • M. WiderströmAffiliated withDepartment of Infectious Diseases, Östersund HospitalDepartment of Clinical Bacteriology, University Hospital of Umeå Email author 
  • , J. WiströmAffiliated withDepartment of Infectious Diseases, University Hospital of Umeå
  • , A. SjöstedtAffiliated withDepartment of Clinical Bacteriology, University Hospital of Umeå
  • , T. MonsenAffiliated withDepartment of Clinical Bacteriology, University Hospital of Umeå

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Coagulase-negative staphylococci (CoNS), originally described as ubiquitous commensals of the healthy human skin and mucosa, have emerged as important opportunistic pathogens primarily causing healthcare-associated infections in patients with indwelling medical devices. Recent studies, utilizing new molecular typing methods, particularly on Staphylococcus epidermidis, have increased our understanding of the mechanisms that contribute to the evolutionary success of these extremely versatile microorganisms. In the following mini-review, we summarize recent research in this area focusing on the molecular methods and epidemiology of S. epidermidis and S. saprophyticus.