European Journal of Clinical Microbiology & Infectious Diseases

, Volume 30, Issue 4, pp 555–559

Evaluation of Helicobacter pylori eradication by triple therapy plus Lactobacillus acidophilus compared to triple therapy alone

  • J. A. da Silva Medeiros
  • T. M. F. O. Gonçalves
  • L. Boyanova
  • M. I. de Correia Pereira
  • J. N. da Silva Paiva de Carvalho
  • A. M. de Sousa Pereira
  • A. M. Silvério Cabrita
Article

DOI: 10.1007/s10096-010-1119-4

Cite this article as:
da Silva Medeiros, J.A., F. O. Gonçalves, T.M., Boyanova, L. et al. Eur J Clin Microbiol Infect Dis (2011) 30: 555. doi:10.1007/s10096-010-1119-4

Abstract

The purpose of this study was to evaluate the influence of adding Lactobacillus acidophilus to a triple regimen for Helicobacter pylori eradication in untreated patients with peptic ulcers or ulcer-scars. This was a pre-randomized, single-blind, interventional, treatment-efficacy study with active controls and parallel-assignment, set in Coimbra, Portugal, on 62 consecutive H. pylori-positive untreated adults with peptic ulcers or ulcer-scars, diagnosed by gastroduodenoscopy, with pre-treatment direct Gram-staining and culture of gastric biopsies. The first 31 patients received esomeprazole 20 mg, amoxicillin 1000 mg and clarithromycin 500 mg (EAC), all b.i.d., for 8 days. The remaining 31 added L. acidophilus, 5 × 109 organisms per capsule, 3 + 2 i.d. for 8 days (EACL). The main outcome measure was 13C urea breath test (UBT), ≥6 weeks after completion of therapy. Successful eradication (UBT-negativity after treatment), was similar in both groups (EAC = 80.6%; EACL = 83.9%, p = 0.740) by both intention-to-treat and per-protocol analysis. The non-eradicated strains were susceptible in vitro to both antibiotics. Adding L. acidophilus to EAC triple therapy did not increase H. pylori eradication rates. Considering the cost and the burden of ingesting five extra capsules daily, supplementing the EAC therapy with L. acidophilus, at this dose, shows no benefit. Further studies with different dosages and duration of treatment, and other probiotics or probiotic combinations are required to improve eradication.

Copyright information

© Springer-Verlag 2011

Authors and Affiliations

  • J. A. da Silva Medeiros
    • 1
    • 6
  • T. M. F. O. Gonçalves
    • 2
  • L. Boyanova
    • 3
  • M. I. de Correia Pereira
    • 1
  • J. N. da Silva Paiva de Carvalho
    • 4
  • A. M. de Sousa Pereira
    • 5
  • A. M. Silvério Cabrita
    • 4
  1. 1.Institute of Physiology, Faculty of MedicineUniversity of CoimbraCoimbraPortugal
  2. 2.Institute of Microbiology, Faculty of MedicineUniversity of CoimbraCoimbraPortugal
  3. 3.Department of MicrobiologyMedical University of SofiaSofiaBulgaria
  4. 4.Institute of Pathology, Faculty of MedicineUniversity of CoimbraCoimbraPortugal
  5. 5.Department of Educational SciencesUniversity of AveiroAveiroPortugal
  6. 6.CoimbraPortugal