Date: 25 Nov 2010

CARD9 Syk-dependent and Raf-1 Syk-independent signaling pathways in target recognition of Candida albicans by Dectin-1

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Abstract

As a principle receptor to β-glucan in the Candida albicans cell wall, Dectin-1 performs recognition specifically and its mechanisms are diverse in different situations. With a view to developing certain antifungal targeted drugs, this review provides new insights into the novel immune signaling pathways induced by Dectin-1, especially the novel understandings of CARD9 in the Syk-dependent NF-κB pathway, and of Raf-1 in the Syk-independent NF-κB signaling pathway.

This work is funded by the Research and Development Program of Science & Technology in Zhejiang of China 2008 C33026 and Zhejiang Medicine Hygiene Science Research 2009A098
Haiping Yang and Hong He are the co-first author, they have contributed equally to this work