Article

European Journal of Clinical Microbiology & Infectious Diseases

, Volume 29, Issue 10, pp 1253-1259

Epidemiology of non-multiresistant methicillin-resistant Staphylococcus aureus infection in Queensland, Australia: associations with indigenous populations and Panton–Valentine leukocidin

  • G. R. NimmoAffiliated withDepartment of Microbiology, Pathology Queensland Central LaboratoryUniversity of Queensland Centre for Clinical ResearchPathology Queensland Central Laboratory, Herston Hospitals Complex Email author 
  • , J. M. SchooneveldtAffiliated withDepartment of Microbiology, Pathology Queensland Central Laboratory
  • , J. L. SutherlandAffiliated withDepartment of Microbiology, Pathology Queensland Central Laboratory
  • , S. PowerAffiliated withDepartment of Microbiology, Pathology Queensland Central Laboratory
  • , D. OlesenAffiliated withCommunicable Diseases Branch, Queensland Health
  • , C. SelveyAffiliated withCommunicable Diseases Branch, Queensland Health
  • , F. BeardAffiliated withCommunicable Diseases Branch, Queensland Health
  • , M. JonesAffiliated withCommunicable Diseases Branch, Queensland Health
  • , D. L. PatersonAffiliated withDepartment of Microbiology, Pathology Queensland Central LaboratoryUniversity of Queensland Centre for Clinical ResearchCommunicable Diseases Branch, Queensland Health

Rent the article at a discount

Rent now

* Final gross prices may vary according to local VAT.

Get Access

Abstract

The purpose of this study was to determine the extent of the spread of epidemic clones of non-multiresistant methicillin-resistant Staphylococcus aureus (nmMRSA) and the epidemiology of resultant infections throughout the state of Queensland. We collected a sample of clinical isolates of nmMRSA from laboratories serving public hospitals and clinics throughout the state. Three hundred isolates were typed and tested for the presence of Panton–Valentine leukocidin (PVL) genes and demographic and clinical data were collected from associated cases. Fifteen percent of S. aureus isolates were nmMRSA and 69% of these belonged to PVL-positive clones, predominantly ST93 and CC30. Low numbers of USA300- and USA400-like isolates were also present. Infections due to PVL-positive strains were much less frequently acquired in hospital (3.4%) than those due to PVL-negative nmMRSA (23.7%). Thirty-seven percent of cases were in indigenous people who make up only 3.6% of the general population. The proportion of cases with PVL-positive, but non-negative isolates decreased progressively with age, suggesting that immunity to PVL might be an important determinant of protection. nmMRSA strains are present throughout Queensland and cause infections in both community and healthcare settings.